0
Allergy and Airway |

Evaluation of Peripheral Sensory Nerves Functions in Patients With Asthma

Dipti Agarwal, MD; Sushma Sood, MD; Prem Parkash Gupta, MD
Author and Funding Information

Dept. of Physiology, PGIMS, Rohtak, India


Chest. 2013;144(4_MeetingAbstracts):80A. doi:10.1378/chest.1698586
Text Size: A A A
Published online

Abstract

SESSION TITLE: Asthma Posters

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 30, 2013 at 01:30 PM - 02:30 PM

PURPOSE: A comparative assessment of peripheral sensory nerves functions in asthma patients organized to two groups according to severity of the disease; and to evaluate for correlation(s) between sensory nerves functions and patients’ characteristics and spirometric indices.

METHODS: Sixty stable asthma patients (40 females and 20 males) diagnosed as per GINA guidelines were included. They were organized to two groups: 30 patients with FEV1/FVC ratio > 70% (Group 1) and 30 patients with FEV1/FVC ratio ≤ 70% (Group 2). Amplitude, latency and conduction velocity of three sensory nerves including median nerve, ulnar nerve and sural nerves were assessed. Significance of difference between identical parameters between groups was analyzed. Correlations between patients` characteristics and spirometric indices with sensory nerve functions parameters were also analyzed.

RESULTS: Both asthma groups were comparable regarding age (28.47±9.24 year vs. 29.67±4.66 year; p value=0.528) and height (p value= 0.738). Group 2 patients had significantly more duration of illness (11.23 ± 3.32 year vs. 5.57 ± 3.18 year) and lower FEV1 (2.130 ± 0.381 L vs. 2.856 ± 0.427 L), lower PEFR (4.879 ± 0.576 L/s vs. 5.988 ± 0.820 L/s). Conduction velocities of all sensory nerves tested were significantly reduced in Group 2. Latencies of ulnar sensory and sural sensory were significantly increased in this group. There was no significant difference between groups regarding amplitude of tested nerves. Duration of illness, FEV1 and PEFR had significant correlations with parameters of sensory nerves functions.

CONCLUSIONS: We observed that patients in severe asthma group had increase in latencies and decrease in conduction velocities of peripheral sensory nerves. We also found that peripheral sensory nerve functions were correlated with duration of illness, FEV1 and PEFR.

CLINICAL IMPLICATIONS: Peripheral sensory nerves are not frequently evaluated in asthma patients. Present study highlights that the peripheral sensory nerve functions may have been affected in many of severe asthma patients. An evaluation may affect the management and improve quality of life in these patients.

DISCLOSURE: The following authors have nothing to disclose: Dipti Agarwal, Sushma Sood, Prem Parkash Gupta

No Product/Research Disclosure Information


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
TRP functions in the broncho-pulmonary system. Semin Immunopathol 2016;38(3):321-9.
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543