Allergy and Airway |

Evaluation of Peripheral Sensory Nerves Functions in Patients With Asthma FREE TO VIEW

Dipti Agarwal, MD; Sushma Sood, MD; Prem Parkash Gupta, MD
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Dept. of Physiology, PGIMS, Rohtak, India

Chest. 2013;144(4_MeetingAbstracts):80A. doi:10.1378/chest.1698586
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SESSION TITLE: Asthma Posters

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 30, 2013 at 01:30 PM - 02:30 PM

PURPOSE: A comparative assessment of peripheral sensory nerves functions in asthma patients organized to two groups according to severity of the disease; and to evaluate for correlation(s) between sensory nerves functions and patients’ characteristics and spirometric indices.

METHODS: Sixty stable asthma patients (40 females and 20 males) diagnosed as per GINA guidelines were included. They were organized to two groups: 30 patients with FEV1/FVC ratio > 70% (Group 1) and 30 patients with FEV1/FVC ratio ≤ 70% (Group 2). Amplitude, latency and conduction velocity of three sensory nerves including median nerve, ulnar nerve and sural nerves were assessed. Significance of difference between identical parameters between groups was analyzed. Correlations between patients` characteristics and spirometric indices with sensory nerve functions parameters were also analyzed.

RESULTS: Both asthma groups were comparable regarding age (28.47±9.24 year vs. 29.67±4.66 year; p value=0.528) and height (p value= 0.738). Group 2 patients had significantly more duration of illness (11.23 ± 3.32 year vs. 5.57 ± 3.18 year) and lower FEV1 (2.130 ± 0.381 L vs. 2.856 ± 0.427 L), lower PEFR (4.879 ± 0.576 L/s vs. 5.988 ± 0.820 L/s). Conduction velocities of all sensory nerves tested were significantly reduced in Group 2. Latencies of ulnar sensory and sural sensory were significantly increased in this group. There was no significant difference between groups regarding amplitude of tested nerves. Duration of illness, FEV1 and PEFR had significant correlations with parameters of sensory nerves functions.

CONCLUSIONS: We observed that patients in severe asthma group had increase in latencies and decrease in conduction velocities of peripheral sensory nerves. We also found that peripheral sensory nerve functions were correlated with duration of illness, FEV1 and PEFR.

CLINICAL IMPLICATIONS: Peripheral sensory nerves are not frequently evaluated in asthma patients. Present study highlights that the peripheral sensory nerve functions may have been affected in many of severe asthma patients. An evaluation may affect the management and improve quality of life in these patients.

DISCLOSURE: The following authors have nothing to disclose: Dipti Agarwal, Sushma Sood, Prem Parkash Gupta

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