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Lung Cancer |

Survival in Lung Cancer and Determinants

Perlat Kapisyzi, PhD; Dhimitraq Argjiri, MD; Eugerta Dilka, MD; Armela Cuko, MD; Roland Kore, MD; Jeta Beli, MD; Elenka Shehu, MD; Ornela Nuredini, MD; Enkelejda Safjani, MD; Eritian Tashi, MD; Edlira Ndreu, MD; Arben Tanka, MD; Esmeralda Nushi, MD; Ilir Skenduli, MD; Mirela Tabaku, PhD
Author and Funding Information

Faculty of Medicine, Tirana, Albania


Chest. 2013;144(4_MeetingAbstracts):657A. doi:10.1378/chest.1697280
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Abstract

SESSION TITLE: Lung Cancer Posters

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 30, 2013 at 01:30 PM - 02:30 PM

PURPOSE: The aim of study was our three-year experience in connection with pulmonary cancer survival and determinant prognostic factors.

METHODS: 255 consecutive cases with pulmonary cancer were studied for a three-year period (2009-2011) at University Hospital of Lung Diseases "Sh. Ndroqi " Tirana. All cases were confirmed by histopathology. Survival was studied for a period of 24 months. We studied the correlation of survival related to factors such as: TNM classification, gender, histological type, age of groups, treatment modality, and lymphocytes in blood. Evaluation of relative survival was realized with Kaplan-Meyer method. Changes are called significant for p <0.05.

RESULTS: Of 255 cases in the study males was 226 (88.6%) and female 29 (11.4%) cases (p <0.001). Regarding the gender, survival was better in female than males (10.2% vs.4.7% respectively), [p = 0.756]. Survival for the age adjusted group <45vjec was 33.3%, versus 11% for age 45-70 years and 5.6% for the age group> 70vjec, [p = 0.001]. Survival in stage IAB was 18%, stage IIAB was 15.7% and IIIA 13.3%. In advanced stages IIIB-IV was 9.5% versus 16.5% for stages I-IIIA, [p = 0.0124].Squamous cell carcinoma and large cell carcinoma have better survival (16.6% and 17.6% respectively), while oat cell carcinoma has the lowest survival (5.5%) [p = 0.0045]. Cases with lymphopenia had lower survival (14.5%), against cases with normal blood lymphocytes (30.6%) and lymphocytosis (21%) [p = 0.014]. Cases treated with surgery had higher survival (20%), compared to those treated with chemioradiotherapi and palliative care (11% and 6% respectively).

CONCLUSIONS: The data of our study show that lung cancer survival for 24 month was 18% in stage IAB, 15.7% in IIAB, 13.3% in IIIA.and 9.5% in stage IIIB-IV.The stage, gender,hystologic type,age,lymphopenia and surgery were the most determinant prognostic factors.

CLINICAL IMPLICATIONS: To evaluate the survival of patients with lung cancer according to prognostic determinants.

DISCLOSURE: The following authors have nothing to disclose: Perlat Kapisyzi, Dhimitraq Argjiri, Eugerta Dilka, Armela Cuko, Roland Kore, Jeta Beli, Elenka Shehu, Ornela Nuredini, Enkelejda Safjani, Eritian Tashi, Edlira Ndreu, Arben Tanka, Esmeralda Nushi, Ilir Skenduli, Mirela Tabaku

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