Diffuse Lung Disease |

Diffusion Parameters and Lung Volumes in Interstitial Lung Diseases FREE TO VIEW

Deniz Demir, MD; Sermin Borekci, MD; Melahat Uygun; Tuncalp Demir, MD; Nurhayat Yildirim, MD
Author and Funding Information

Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey

Chest. 2013;144(4_MeetingAbstracts):476A. doi:10.1378/chest.1680113
Text Size: A A A
Published online


SESSION TITLE: Interstitial Lung Disease Posters

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 30, 2013 at 01:30 PM - 02:30 PM

PURPOSE: Interstitial lung diseases impair the mechanical properties and gas diffusion of the lung. Restrictive respiratory disorder are most commonly observed , DLCO is reduced , DLCO/VA is increased. DLCO/VA value gives info about function of alveolo-capillary membrane, and VA/TLC value gives info about the equivalence of ventilation. In this study we aimed to evaluate the diffusion parameters and lung volumes together in interstitial lung diseases; and aimed to comment in clinical practice.

METHODS: Between January 2002 and November 2012, all diffusion test parameters and lung volume parameters of patients with the interstitial lung disease diagnosis who admitted to Cerrahpasa medical school pulmonary function test laboratory were retrospectively evaluated. DLCO%, DLCO/VA%, VA/TLC% values of patients were evaluated. Statistical analysis was done by using SPSS 15.0 software.

RESULTS: 40 (70%) of 57 cases were female, 17(30%) were male, mean age was 51.85±13.05 years. At admision the distribution of primary diseases was; 29 (51%) patients were scleroderma, 16(28%) idiopathic pulmonary fibrosis, 9 (16%) sarcoidosis, 2(4%) rheumatoid arthritis with pulmonary involvement, 1(%2) hypersensitivity pneumonitis. DLCO% was found decreased in 53 cases (mean:48%). 29 (55%) of 53 cases has decreased DLCO/VA% (mean:72%), and VA/TLC% was decreased in 4 (14%) of 29 cases (mean:61%). DLCO/VA% value was normal in 24 (45%)patients, but VA/TLC% was decreased in 5(21%) of them (mean:76%). There was not differance between groups of disease according to DLCO%, DLCO/VA%, and VA/TLC% values.

CONCLUSIONS: In most of interstitial lung disease; diffusion is impaired, alveolo capillary membrane function is affected; despite these, equivalence of ventilation is preserved

CLINICAL IMPLICATIONS: This study shows the using of diffusion parameters and lung volumes together in interstitial lung diseases in clinical practice.

DISCLOSURE: The following authors have nothing to disclose: Deniz Demir, Sermin Borekci, Melahat Uygun, Tuncalp Demir, Nurhayat Yildirim

No Product/Research Disclosure Information




Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543