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Pulmonary Rehabilitation |

FEV3, FEV3/FVC and 1-FEV3/FVC in Obstructive Lung Disease

Tuncalp Demir, MD; Sermin Borekci, MD; Melahat Uygun; Deniz Demir, MD; Nurhayat Yildirim, MD
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Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey


Chest. 2013;144(4_MeetingAbstracts):842A. doi:10.1378/chest.1680036
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Abstract

SESSION TITLE: Physiology/PFTs/Rehabilitation Posters

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 30, 2013 at 01:30 PM - 02:30 PM

PURPOSE: 1-FEV3/FVC refers to the fraction of the forced vital capacity (FVC) that had not been expired during the first 3 s of the FVC. In recent years, some studies defined that 1-FEV3/FVC could be used to evalute the small airways. In this study we aimed to determine the usefulness of 1-FEV3/FVC, and the relationship of it with the other parameters in obstructive lung diseases.

METHODS: Between 2005-2012 years, the results of 1100 cases whose lung volumes were measured by body plethysmography in Cerrahpasa Medical School Pulmonary Function Test Laboratory, were evaluated retrospectively.

RESULTS: 607(54.7%) of 1100 cases were male , 503 (45,3%) were female, mean age was 52.5±15.6 years, mean value of FEV3/FVC was 87.05% and mean value of 1-FEV3/FVC was 12%. Obstructive (FEV1/FVC<70%) and non-obstructive groups were compared; mean value of FEV3/FVC was 95.1% in non-obstructive group, 75.9% in obstructive group; mean value of 1-FEV3/FVC was 4.9 in non-obstructive group, 24.08 inobstructive group (Table 1). We determined positive correlation between 1-FEV3/FVC and RV (r=0.631), TGV (r=0.672; p<0.01), TLC (r=0.521; p<0.01) ; negative correlation between 1- FEV3/FVC and FEF25-75 (r=-0.657; p<0.01) .

CONCLUSIONS: In obstructive lung diseases, while FEV3 is decreased, 1-FEV3/FVC is increased, and this is correlated with over inflation parameters (TGV, RV, TLC). However the increase in 1-FEV3/FVC may show small airway disease, also it can be only an indication of sign of over inflation. 1-FEV3/FVC can be used to demonstrate over inflation, especially when the lung volumes can not be measured.

CLINICAL IMPLICATIONS: 1-FEV3/FVC can be used to demonstrate over inflation, especially when the lung volumes can not be measured.

DISCLOSURE: The following authors have nothing to disclose: Tuncalp Demir, Sermin Borekci, Melahat Uygun, Deniz Demir, Nurhayat Yildirim

No Product/Research Disclosure Information


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