Pediatrics |

In Children With Family History of Asthma, Does Gender Increase Their Risk for Asthma FREE TO VIEW

Shahid Sheikh, MD; Judy Pitts, APN; Nancy Ryan-Wenger, PhD; Karen McCoy, MD
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Division of Pulmonary Medicine, Department of Pediatrics, Nationwide Children Hospital/Ohio State University, Columbus, OH

Chest. 2013;144(4_MeetingAbstracts):763A. doi:10.1378/chest.1675911
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SESSION TITLE: Pediatric Asthma Posters

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 30, 2013 at 01:30 PM - 02:30 PM

PURPOSE: It is known that children with family history of asthma are at higher risk of developing asthma. It is not clear if gender of patients play any role in genetics of asthma. We hypothesized that among patients with a positive family history of asthma, there could be ncreased risk of asthma based on gender of the patient or family member of with asthma.

METHODS: After IRB approval, we analyzed data from our Pediatric Asthma Center, established at Nationwide Children’s Hospital in 2010. Families at their first visit were given a questionnaire that included information on family history of asthma, including mother, father, or both, and grandmother, grandfather or both.

RESULTS: Of 542 patients, 317 (58%) were males and 225 (41.4%) were females. Mean age in years was 7 ±4, mean age at diagnosis was 2.7 ±2.4, and mean duration of symptoms was 4.5 ±3.7 years. A positive family history of asthma was reported for 338 (74%) patients. Family members with asthma included 149 (27.4%) mothers, 110 (20.3%) fathers, 63 (18.6%) grandmothers, and 12 (3.6%) grandfathers. Among patients whose mother had asthma, there were no significant differences between female patients (n=66, 44.3%) and male patients (n=83, 55.7%; p=0.393). When the father had asthma, no differences were noted between male patients (n=66, 60%) and female patients (n=44, 40%; p=0.741). If both mothers and fathers had a history of asthma, there were no differences between female and male patients (4.2% vs. 5.2%, p=0.584). The same patterns were noted between male patients and grandfathers, and female patients and grandmothers. However, if either grandparent had a history of asthma, there was an increased risk of asthma in grand-daughters compared to grandsons (22% vs. 15%, p=0.048).

CONCLUSIONS: These data suggest that there is no evidence of gender-specific increased risk for female or male patients when the mother or father has asthma. Family history of asthma in grandparent may be a significant risk factor for asthma in grand daughters comapred to grand sons. Thus genetics of asthma may skip generations.

CLINICAL IMPLICATIONS: Better understanding of family history of asthma can help in better understanding of complex genetics of Asthma.

DISCLOSURE: The following authors have nothing to disclose: Shahid Sheikh, Judy Pitts, Nancy Ryan-Wenger, Karen McCoy

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