Allergy and Airway |

Relationship of Obesity With Airway Hyperresponsiveness in Methacholine Challenge Testing FREE TO VIEW

Nader Mahmood, MD; Ayham Aboeed, MD; Suresh Kumar Manickavel, MBBS; M. Khan, MD
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St. Joseph's Regional Medical Center, Paterson, NJ

Chest. 2013;144(4_MeetingAbstracts):73A. doi:10.1378/chest.1659444
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SESSION TITLE: Asthma Posters

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 30, 2013 at 01:30 PM - 02:30 PM

PURPOSE: Asthma and obesity are a significant public health concern and the prevalence of both is on the rise. Epidemiological data has linked obesity with an increased risk for developing asthma. The relationship of bronchial hyperresponsiveness to methacholine in obesity is unclear. We examined the relationship of body mass index (BMI) with airway hyperresponsiveness in methacholine challenge testing.

METHODS: We conducted a retrospective study over a period of two years from January 1, 2009 to December 31, 2010. The patients had experienced asthma symptoms but had a ratio of forced expiratory volume in the first second of expiration (FEV1) to forced vital capacity (FVC) of > 70%. Airway hyperresponsiveness was assessed by concentration of methacholine needed to cause a 20% decrease in FEV1 (PC20). The cohort included 42 patients. This cohort was then divided based on BMI into two categories: non-obese (BMI < 30) and obese (BMI ≥ 30).

RESULTS: There were 19 obese patients and 24 non-obese patients. There were 15 males and 27 females. A significant difference was observed for FEV1 change on methacholine challenge (Non-obese 10.4 [±6.9], Obese 15.7 [±8.5], p = 0.0308 with Mann Whitney Test). The odds ratio for airway hyperresponsiveness with obesity was 4.86 (95% Confidence Interval 1.30 to 18.13); p = 0.0277.

CONCLUSIONS: In this study obesity appears to be associated with demonstration of airway hyperresponsiveness to methacholine. The exact mechanism by which obesity and asthma are associated remains a topic of further research.

CLINICAL IMPLICATIONS: This data continues to suggest a relationship with asthma and obesity. Future research may show that weight loss has an impact on improving airway hyperresponsiveness.

DISCLOSURE: The following authors have nothing to disclose: Nader Mahmood, Ayham Aboeed, Suresh Kumar Manickavel, M. Khan

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