As mentioned by Dr Balta and colleagues, there is growing evidence in support of an independent association between OSA and cardiovascular diseases. Therefore, we entered into our multivariate regression analyses most cardiovascular diseases associated with OSA, including hypertension, ischemic heart disease, cardiac arrhythmia, congestive heart failure, and stroke. Recently, a high prevalence of OSA was observed in patients needing surgery for peripheral arterial disease.5 We acknowledge that a medical history of peripheral arterial disease has not been recorded in our database. Screening for pulmonary hypertension requires additional investigation, such as echocardiography. In isolation, OSA typically causes only mild pulmonary hypertension that does not require specific treatment. We acknowledge that renal, hepatic, and thyroid dysfunction may be observed in patients with OSA; however, in our large multisite study, biologic investigations were limited to those recommended by French guidelines for the management of OSA in routine practice, including fasting blood glucose, glycated hemoglobin, and fasting serum lipid levels.