Recently in CHEST (May 2013), Stuijver and colleagues1 suggested that iatrogenic corticosteroids are risk factors for pulmonary embolism as much as endogenous steroids are associated with an increased risk of thrombosis. In this context, it is useful to note that thrombotic risk with corticosteroids not only is restricted to venous circulation but also involves the arterial side. A recent study by Fardet and colleagues2 suggested that iatrogenic corticosteroids are risk factors for cardiovascular disease. This analysis, as in the present study, possibly reflects the increased cardiovascular risk associated with the disease conditions for which steroids are prescribed. Subclinical atherosclerosis is noted in many conditions where chronic inflammation is a pathophysiologic factor.3 However, Fardet and colleagues2 noted cardiovascular events with long-term use of corticosteroids but not venous thrombosis. In these cases, long-term suppression of the underlying inflammatory state would have been necessary. In other words, steroid use in the initial period of the prescription and at higher doses is an additional risk factor for venous thrombosis, whereas smaller-dose, long-term prescriptions are risk factors for arterial thrombosis.