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An Opportunistic Infection Associated With Ruxolitinib, a Novel Janus Kinase 1,2 InhibitorAn Infection With New Janus Kinase Inhibitor

Nicholas G. Wysham, MD; Donald R. Sullivan, MD; Gopal Allada, MD
Author and Funding Information

From the Department of Internal Medicine (Dr Wysham) and Department of Pulmonary and Critical Care Medicine (Drs Sullivan and Allada), Oregon Health and Science University, Portland, OR.

Correspondence to: Gopal Allada, MD, Department of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Mail Code UHN-67, 3181 SW Sam Jackson Park Rd, Portland, OR 97239-3098; e-mail: alladag@ohsu.edu


Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2013;143(5):1478-1479. doi:10.1378/chest.12-1604
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We report a case of Cryptococcus neoformans pneumonia in a patient taking ruxolitinib, a janus kinase 1,2 inhibitor approved for the treatment of myelofibrosis. We hypothesize that ruxolitinib contributed to this infection through its effects on cell-mediated immunity. Clinicians should be aware of the potential for intracellular or opportunistic infections associated with this novel drug class.

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