The widespread use of antibiotics has been paralleled by the development of resistance in bacteria. It is, thus, necessary for us to use antibiotics wisely and appropriately. Getting therapy right the first time has been crucial in improving outcomes in severe infections, reducing all-cause 30-day mortality and hospital length of stay. Knowing your local organisms and susceptibilities is crucial to getting it right the first time.1 This will largely determine your antibiotic choices. In turn, overuse of antibiotics will drive more resistance.