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Systemic Treatment of Advanced Lung Carcinoid TumorsSystemic Treatment of Advanced Lung Carcinoid: Show Me the Data!

James R. Jett, MD, FCCP; Laurie L. Carr, MD
Author and Funding Information

From the Division of Oncology, National Jewish Health.

Correspondence to: James R. Jett, MD, FCCP, Division of Oncology, National Jewish Health, 1400 Jackson St, Denver, CO 80206; e-mail: jettj@njhealth.org


Financial/nonfinancial disclosures: The authors have reported to CHEST the following conflicts of interest: Dr Jett has received research grants paid to National Jewish Health from Oncimmune (USA) LLC (biomarkers) and Metabolomx (breath analysis). Dr Carr has reported that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2013;143(4):884-886. doi:10.1378/chest.12-2455
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Extract

Neuroendocrine tumors (NETs) arise in most organs of the body and are generally divided into well-differentiated (low grade [G1] and intermediate [G2]) and poorly differentiated tumors. NETs of the foregut includes lung, thymus, stomach, duodenum, and pancreas.1,2 Bronchial carcinoid tumors are divided into typical (low grade, G1) and atypical (intermediate, G2) based on a mitotic rate of fewer than two mitoses per 2 mm2 (10 high-power fields) and no necrosis or presence of two to 10 mitoses per 2 mm2 or the presence of necrosis. Although one-half of bronchial carcinoid tumors are localized at the time of diagnosis, approximately 25% have regional and 25% have distant metastases as reported in the Surveillance Epidemiology and End Results (SEER) program database (1973-2004).3 The median survival time for metastatic or stage IV is 16 months.3

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