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Postgraduate Education Corner: Pulmonary, Critical Care, and Sleep Pearls |

A 46-Year-Old Woman With Atelectasis From an Endobronchial TumorA 46-Year-Old Woman With Atelectasis

Takeshi Uenami, MD; Takashi Kijima, MD, PhD; Masahiro Ayata, MD; Yoshitomo Hayama, MD; Naotoshi Tsuruta, MD; Yoshiyuki Saito, MD, PhD; Takashi Niju, MD; Naozumi Higaki, MD; Toshiyuki Ikeda, MD, PhD
Author and Funding Information

From the Department of Respiratory Medicine (Drs Uenami, Hayama, Tsuruta, Saito, Niju, and Ikeda), Department of Pathology (Dr Ayata), and Department of Respiratory Surgery (Dr Higaki), Nishinomiya Municipal Central Hospital, Hyogo; and Department of Respiratory Medicine, Allergy and Rheumatic Diseases (Dr Kijima), Graduate School of Medicine/Faculty of Medicine, Osaka University, Osaka, Japan.

Correspondence to: Takeshi Uenami, MD, Department of Respiratory Medicine, Nishinomiya Municipal Central Hospital, 8-24 Hayashida-cho, Nishinomiya, Hyogo 663-8014, Japan; e-mail: med31@nishi-hp.jp


Drs Uenami and Kijima contributed equally to this article as first authors.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2013;143(4):1170-1173. doi:10.1378/chest.12-1874
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Drs Uenami and Kijima contributed equally to this article as first authors.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.

PettinatoGManivelJCDe RosaNDehnerLP. Inflammatory myofibroblastic tumor (plasma cell granuloma). Clinicopathologic study of 20 cases with immunohistochemical and ultrastructural observations. Am J Clin Pathol. 1990;94(5):538-546.CoffinCMPatelAPerkinsSElenitoba-JohnsonKSPerlmanEGriffinCA. ALK1 and p80 expression and chromosomal rearrangements involving 2p23 in inflammatory myofibroblastic tumor. Mod Pathol. 2001;14(6):569-576.TravisWDElisabethBMuller-HermelinkHKHarrisCC, eds.Pathology and Genetics of Tumours of the Lung, Pleural, Thymus and Heart. Lyon, France: IARC Press; 2004.CoffinCMHornickJLFletcherCD. Inflammatory myofibroblastic tumor: comparison of clinicopathologic, histologic, and immunohistochemical features including ALK expression in atypical and aggressive cases. Am J Surg Pathol. 2007;31(4):509-520.GleasonBCHornickJL. Inflammatory myofibroblastic tumours: where are we now?J Clin Pathol. 2008;61(4):428-437.TakeuchiKChoiYLTogashiY. KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer. Clin Cancer Res. 2009;15(9):3143-3149.ButrynskiJED’AdamoDRHornickJL. Crizotinib in ALK-rearranged inflammatory myofibroblastic tumor. N Engl J Med. 2010;363(18):1727-1733.DuaSGPurandareNPrameshCS. Fluoro-deoxy glucose-avid endobronchial inflammatory myofibroblastic tumor mimicking bronchial malignancy: report of a case. J Cancer Res Ther. 2011;7(3):340-343.TakeuchiKSodaMTogashiY. Pulmonary inflammatory myofibroblastic tumor expressing a novel fusion, PPFIBP1-ALK: reappraisal of anti-ALK immunohistochemistry as a tool for novel ALK fusion identification. Clin Cancer Res. 2011;17(10):3341-3348.

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