The pathophysiology and neurobiology of catatonia are largely unknown. Because much of the treatment of catatonia involves the γ-aminobutyric acid-A, glutamate, and dopamine systems, it is hypothesized that the disorder involves a dysregulation of the former neurotransmitters. However, few clinical studies have demonstrated a causative link between the former and catatonia. Catatonia can be secondary to a psychiatric disorder (ie, schizophrenia), a neurologic disorder (ie, encephalitis, meningitis, seizure, or structural damage), or medical conditions (eg, systemic lupus erythematosis, phencyclidine use, among >100 conditions reported). Catatonia has also been described secondary to steroid use, which was likely the cause in this patient.