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Cardiovascular Disease in COPDCardiovascular Disease in COPD: Mechanisms: Mechanisms

John D. Maclay, MBChB, MD; William MacNee, MBChB, MD
Author and Funding Information

From Gartnavel General Hospital (Dr Maclay), Glasgow; and MRC Centre for Inflammation Research (Prof MacNee), The Edinburgh University, Edinburgh, Scotland.

Correspondence to: William MacNee, MBChB, MD, ELEGI Colt Laboratory, Queen’s Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, Scotland; e-mail: w.macnee@ed.ac.uk


Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2013;143(3):798-807. doi:10.1378/chest.12-0938
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It is now well established that cardiovascular disease contributes significantly to both morbidity and mortality in COPD. Shared risk factors for cardiovascular disease and COPD, such as smoking, low socioeconomic class, and a sedentary lifestyle contribute to the natural history of each of these conditions. However, it is now apparent that alternative, novel mechanisms are involved in the pathogenesis of cardiovascular disease, and these may play an important role in driving the increased cardiovascular risk associated with COPD. In this article, we discuss the potential mechanisms that link COPD to an increased risk of cardiovascular disease.

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