Imagine a set of assumptions that proves entirely incorrect. You order a peripherally inserted central catheter (PICC) for your hospitalized patient. False assumption 1: This is a PICC team procedure, and physicians do not really need to give this order much thought. The PICC team will figure out the largest catheter that can be safely inserted. At most, you will specify whether you want a single-, double-, or triple-lumen catheter. If unsure, order double lumen rather than single lumen or order triple lumen rather than double lumen; after all, to minimize the number of procedures, it is better to err on having more rather than fewer sites to infuse medications, blood products, and nutritional support. Eventually, the PICC will stop working. Its duration of function is mostly a matter of luck. The catheter may thrombose, but this is a minor problem. False assumption 2: An upper-extremity line-associated DVT is nothing more than a nuisance. It adds hardly a blip to the length of hospital stay and barely registers on the radar screen for incremental cost of hospitalization.