In the evaluation of GGOs, benign lesions usually resolved partially or completely by CT scan recheck 3 months later.4 In our practice, when the nature of GGOs, especially those with a relatively large size, is still uncertain at 3 months, CT scan-guided biopsy is recommended to patients. In our experience, the success rate of biopsy is relatively high when the diameter of a GGO is >7 mm. Our biopsy cases all produced pathologic results, which were consistent with the subsequent results of surgical specimens. All these cases were adenocarcinoma or bronchioloalveolar carcinoma. In a study by Kim et al,5 CT scan-guided biopsy was also reported as effective in giving value to the nature of GGO, with a sensitivity of 93% and an accuracy of 91%. Therefore, we recommend that after a short-term follow-up, CT scan-guided biopsy be given as a choice for the evaluation of GGO with a relatively large diameter.