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T Helper 17 Cells in Airway DiseasesT Helper 17 Cells in Respiratory Diseases: From Laboratory Bench to Bedside

Rabih Halwani, PhD; Saleh Al-Muhsen, MD; Qutayba Hamid, MD, PhD
Author and Funding Information

From the Prince Naif Center for Immunology Research (Drs Halwani, Al-Muhsen, and Hamid), College of Medicine, King Saud University, Riyadh, Saudi Arabia; and Meakins-Christie Laboratories (Dr Hamid), Faculty of Medicine, McGill University, Montreal, QC, Canada.

Correspondence to: Qutayba Hamid, MD, PhD, Meakins-Christie Laboratories, McGill University, 3626 Rue St Urbain, Montreal, QC, H2X 2P2, Canada; e-mail: qutayba.hamid@mcgill.ca


Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2013;143(2):494-501. doi:10.1378/chest.12-0598
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T helper 17 (Th17) cytokines are now widely believed to be critical for the regulation of various chronic immune diseases. Investigations have revealed a significant role for IL-17 cytokines in regulating inflammation and modulating lung and airway structural cells in asthma and COPD. In this review, our current understanding of the role of Th17-associated cytokines in airway diseases is summarized. Therapeutic approaches targeting IL-17 during asthma and COPD are also discussed.

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