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Correspondence |

Obstructive Sleep Apnea Is Associated With Increased High-Sensitivity Cardiac Troponin T LevelsObstructive Sleep Apnea Troponin FREE TO VIEW

Edgar Argulian, MD, MPH
Author and Funding Information

From the Division of Cardiology, St. Luke’s-Roosevelt Hospital Center, Columbia University College of Physicians & Surgeons, New York, NY.

Correspondence to: Edgar Argulian, MD, MPH, Division of Cardiology, St. Luke’s-Roosevelt Hospital Center, Columbia University College of Physicians & Surgeons, 1111 Amsterdam Ave, New York, NY 10025; e-mail: eargulian@chpnet.org


Financial/nonfinancial disclosures: The author has reported to CHEST that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2013;143(1):277-278. doi:10.1378/chest.12-2186
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To the Editor:

The study by Randby et al1 in an issue of CHEST (September 2012) explores the association between the severity of obstructive sleep apnea and circulating levels of high-sensitivity cardiac troponin T (hs-cTnT) in the general population. The prevalence of measurable hs-cTnT was 43%, which the authors state is high.

In the Dallas Heart Study, the prevalence of detectable hs-cTnT was 24% in participants aged 40-50 years and 41% in participants aged 50-60 years.2 In the Atherosclerosis Risk in Communities (ARIC) Study, 67% of participants had measurable hs-cTnT levels using the same cutoff. Although the ARIC subjects were older than the current study population, they were free of coronary disease and stroke at baseline.3 Although even minimally elevated hs-cTnT was associated with increased mortality in the ARIC study, it was the highest category that carried the dramatic excess of adverse events. Was the significance of high levels of measurable hs-cTnT (eg, the top quartile) in association with obstructive sleep apnea severity analyzed by Randby et al1?

References

Randby A, Namtvedt SK, Einvik G, et al. Obstructive sleep apnea is associated with increased high-sensitivity cardiac troponin T levels. Chest. 2012;142(3):639-646. [CrossRef] [PubMed]
 
de Lemos JA, Drazner MH, Omland T, et al. Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population. JAMA. 2010;304(22):2503-2512. [CrossRef] [PubMed]
 
Saunders JT, Nambi V, de Lemos JA, et al. Cardiac troponin T measured by a highly sensitive assay predicts coronary heart disease, heart failure, and mortality in the Atherosclerosis Risk in Communities Study. Circulation. 2011;123(13):1367-1376. [CrossRef] [PubMed]
 

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References

Randby A, Namtvedt SK, Einvik G, et al. Obstructive sleep apnea is associated with increased high-sensitivity cardiac troponin T levels. Chest. 2012;142(3):639-646. [CrossRef] [PubMed]
 
de Lemos JA, Drazner MH, Omland T, et al. Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population. JAMA. 2010;304(22):2503-2512. [CrossRef] [PubMed]
 
Saunders JT, Nambi V, de Lemos JA, et al. Cardiac troponin T measured by a highly sensitive assay predicts coronary heart disease, heart failure, and mortality in the Atherosclerosis Risk in Communities Study. Circulation. 2011;123(13):1367-1376. [CrossRef] [PubMed]
 
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