In this issue of CHEST (see page 64), Hariri and colleagues1 provide a tantalizing look at a technology that promises to improve biopsy sampling of the lung and to perhaps offer even more to patients with lung diseases. Defining “more” is the essence of the challenge put forth by this illuminating article, which describes the authors’ well-designed correlative evaluation of images acquired by volumetric optical frequency domain imaging (OFDI) and histopathology. Volumetric OFDI is an optical coherence tomography (OCT) imaging technology with rapid acquisition rates that can provide high-resolution images in time frames compatible with clinical usage. OCT, described in 1991 by Huang and colleagues,2 is a noninvasive modality that uses interferometry to produce an image of optical scattering from internal tissue microstructures. This technology can generate two- and three-dimensional images of tissues at resolutions comparable to low-power light microscopy, with tissue penetration depths of several millimeters. Components of the bronchial wall can be resolved, and image representations of architecturally altering processes such as tumors and inflammatory disorders can be generated. Volumetric OFDI can be employed during flexible bronchoscopy or via a needle-based approach.