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Procalcitonin-Guided Antibiotic Therapy in COPD Exacerbations: Closer But Not Quite There

Fernando J. Martinez, MD, MS, FCCP; Jeffrey L. Curtis, MD
Author and Funding Information

Affiliations: Ann Arbor, MI ,  Dr. Martinez is Professor of Internal Medicine, and Dr. Curtis is Professor of Internal Medicine and VA Section Chief, Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, and Veterans Administration Healthcare System.

Correspondence to: Fernando J. Martinez, MD, MS, FCCP, The University of Michigan Health System, 1500 E Medical Center Dr, 3916 Taubman Center, Box 0360, Ann Arbor, MI 48109; e-mail: fmartine@umich.edu


Chest. 2007;131(1):1-2. doi:10.1378/chest.06-2567
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Comprehensive, evidence-based reviews12 on the management of acute exacerbations of COPD (AECOPD) recommend a multifaceted approach. That this approach includes antibiotics should not be surprising, given compelling data that bacterial infection is the likely cause in approximately 50% of AECOPD.3 Yet, despite numerous published placebo-controlled trials,3 and systematic reviews1,46 suggesting an overall treatment effect, the role of antimicrobials in AECOPD remains controversial.7 This topic is clearly ripe for a conceptual breakthrough.


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