Quality Assessment | Summary of Findings |
| | | | | | | Study Event Rates (%) | | Anticipated Absolute Effects |
Participants (Studies), Follow-up | Risk of Bias | Inconsistency | Indirectness | Imprecision | Publication Bias | Overall Quality of Evidence | With No Extended Anticoagulation | With Extended Anticoagulation | Relative Effect (95% CI) | Risk With No Extended Anticoagulation | Risk Difference With Extended Anticoagulation (95% CI) |
Mortality (important outcome) |
1,184 (4 studies), 10-36 mo | No serious risk of bias | No serious inconsistency^{c} | No serious indirectness | Serious^{d,e} | Undetected | Moderate^{c-e} due to imprecision | 38/599 (6.3%) | 16/585 (2.7%) | RR 0.57 (0.31-1.03) | 63 per 1,000 | 27 fewer per 1,000 (from 44 fewer to 2 more) |
Recurrent VTE at 1 y (critical outcome) |
1,184 (4 studies), 10-36 mo | No serious risk of bias | No serious inconsistency | No serious indirectness | No serious imprecision | Undetected | High | 102/599 (17%) | 21/585 (3.6%) | RR 0.12 (0.05-0.25) | First VTE provoked by surgery^{f-j} |
| | | | | | | | | | 10 per 1,000 | 9 fewer per 1,000 (from 7 fewer to 9 fewer) |
| |
| | | | | | | | | | First VTE provoked nonsurgical/first unprovoked distal DVT^{f-j} |
| | | | | | | | | | 50 per 1,000 | 44 fewer per 1,000 (from 38 fewer to 47 fewer) |
| |
| | | | | | | | | | First unprovoked VTE^{f-j} |
| | | | | | | | | | 100 per 1,000 | 88 fewer per 1,000 (from 75 fewer to 95 fewer) |
| |
| | | | | | | | | | Second unprovoked VTE^{f-j} |
| | | | | | | | | | 150 per 1,000 | 132 fewer per 1,000 (from 113 fewer to 142 fewer) |
| |
Major bleeding at 1 y (critical outcome) |
1,184 (4 studies), 10-36 mo | No serious risk of bias | No serious inconsistency | No serious indirectness | Serious | Undetected | Moderate due to imprecision | 7/599 (1.2%) | 21/585 (3.6%) | RR 2.63 (1.02-6.76) | Low risk of bleeding^{k,l} |
| | | | | | | | | | 3 per 1,000 | 5 more per 1,000 (from 0 more to 17 more) |
| |
| | | | | | | | | | Moderate risk of bleeding^{k,l} |
| | | | | | | | | | 6 per 1,000 | 10 more per 1,000 (from 0 more to 35 more) |
| |
| | | | | | | | | | High risk of bleeding^{k,l} |
| | | | | | | | | | 24 per 1,000 | 39 more per 1,000 (from 0 more to 138 more) |
| |
Recurrent VTE at 5 y (critical outcome) |
1,184 (4 studies), 10-36 mo | No serious risk of bias | No serious inconsistency | No serious indirectness | No serious imprecision | Undetected | High | 102/599 (17%) | 21/585 (3.6%) | RR 0.12 (0.05-0.25) | First VTE provoked by surgery^{f-j} |
| | | | | | | | | | 30 per 1,000 | 26 fewer per 1,000 (from 22 fewer to 29 fewer) |
| |
| | | | | | | | | | First VTE provoked nonsurgical/first unprovoked distal DVT^{f-j} |
| | | | | | | | | | 150 per 1,000 | 132 fewer per 1,000 (from 113 fewer to 142 fewer) |
| |
| | | | | | | | | | First unprovoked VTE^{f-j} |
| | | | | | | | | | 300 per 1,000 | 264 fewer per 1,000 (from 225 fewer to 285 fewer) |
| |
| | | | | | | | | | Second unprovoked VTE^{f-j} |
| | | | | | | | | | 450 per 1,000 | 396 fewer per 1,000 (from 337 fewer to 427 fewer) |
| |
Major bleeding at 5 y (critical outcome) |
1,184 (4 studies), 10-36 mo | No serious risk of bias | No serious inconsistency | No serious indirectness | Serious | Undetected | Moderate due to imprecision | 7/599 (1.2%) | 21/585 (3.6%) | RR 2.63 (1.02-6.77) | Low risk of bleeding^{k,l} |
| | | | | | | | | | 15 per 1,000 | 24 more per 1,000 (from 0 more to 87 more) |
| |
| | | | | | | | | | Moderate risk of bleeding^{k,l} |
| | | | | | | | | | 30 per 1,000 | 49 more per 1,000 (from 1 more to 173 more) |
| |
| | | | | | | | | | High risk of bleeding^{k,l} |
| | | | | | | | | | 120 per 1,000 | 196 more per 1,000 (from 2 more to 692 more) |
| |
Burden of anticoagulation not reported |
… | … | … | … | … | … | … | … | … | … | See comment^{m} | See commentm |
PTS not reported |
… | … | … | … | … | … | … | … | … | … | See comment^{n} | See comment^{n} |