Again, this variant is also associated with hepatocellular carcinoma risk and prognosis.3 As a stress-inducible endoplasmic reticulum calcium-binding chaperone, GRP78 is used extensively as a biologic marker for onset of the unfolded protein response as well as a unique model for deciphering the mechanisms whereby endoplasmic reticulum stress upregulates nuclear gene expression.4 Here, we studied the possible association of rs430397 and NSCLC risk in China. An association analysis was carried out in the samples described.2,3 This study was approved by the ethics committee of Sun Yat-sen University. Additionally, all participants (or their guardians when necessary) provided written informed consent. The genotype-specific risks were estimated as ORs with associated 95% CIs using Pearson χ2 test. A trend test of ORs was used to assess an allele dose-dependent effect. As shown in Table 1, genotypes GG, AG, and AA are not associated with NSCLC risk, but the distribution trend of genotype shows some significance (Ptrend = .035). These data show that rs430397 is still not a risk factor of NSCLC. In addition to our previous results,3,5 we infer that intronic rs430397 mutation is still a controversial and indecisive contributing factor during the occurrence of disease stress.