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Postgraduate Education Corner: Pulmonary and Critical Care Pearls |

A 32-Year-Old Man With Persistent Cough, Shortness of Breath, Eosinophilic Pneumonia, and Peripheral Blood EosinophiliaEosinophilic Pneumonia and Peripheral Eosinophilia

Nasheed M. Hossain, MD; Nitin Jain, MD; Jamie L. Steinmetz, MD; John F. McConville, MD; John Anastasi, MD; Olatoyosi Odenike, MD
Author and Funding Information

From the Department of Medicine, Section of Internal Medicine (Dr Hossain), Department of Medicine, Section of Hematology/Oncology (Drs Jain and Odenike), Department of Pathology (Dr Steinmetz), Department of Medicine, Section of Pulmonary/Critical Care (Dr McConville), Department of Pathology, Section of Hematopathology (Dr Anastasi), and The University of Chicago Comprehensive Cancer Center (Drs Anastasi and Odenike), University of Chicago Medical Center, Chicago, IL.

Correspondence to: Olatoyosi Odenike, MD, Department of Medicine, Section of Hematology/Oncology, 5841 S Maryland, MC 2115, Chicago, IL 60637; e-mail: todenike@medicine.bsd.uchicago.edu

Drs Hossain and Jain contributed equally to the work.


Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2012;142(6):1680-1683. doi:10.1378/chest.12-0652
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Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.

CoolsJDeAngeloDJGotlibJ. A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med. 2003;348(13):1201-1214.PardananiAKetterlingRPLiCY. FIP1L1-PDGFRA in eosinophilic disorders: prevalence in routine clinical practice, long-term experience with imatinib therapy, and a critical review of the literature. Leuk Res. 2006;30(8):965-970.BaccaraniMCilloniDRondoniM. The efficacy of imatinib mesylate in patients with FIP1L1-PDGFRalpha-positive hypereosinophilic syndrome. Results of a multicenter prospective study. Haematologica. 2007;92(9):1173-1179.TefferiAVardimanJW. Classification and diagnosis of myeloproliferative neoplasms: the 2008 World Health Organization criteria and point-of-care diagnostic algorithms. Leukemia. 2008;22(1):14-22.OgboguPUBochnerBSButterfieldJH. Hypereosinophilic syndrome: a multicenter, retrospective analysis of clinical characteristics and response to therapy. J Allergy Clin Immunol. 2009;124(6):1319-1325.TefferiAGotlibJPardananiA. Hypereosinophilic syndrome and clonal eosinophilia: point-of-care diagnostic algorithm and treatment update. Mayo Clinic Proc. 2010;85(2):158-164.Fernández PérezEROlsonALFrankelSK. Eosinophilic lung diseases. Med Clin North Am. 2011;95(6):1163-1187.KlionAD. Eosinophilic myeloproliferative disorders. Hematology Am Soc Hematol Educ Program. 2011;2011:257-263.

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