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Severe Pulmonary Hypertension Associated With EmphysemaEmphysema and Pulmonary Hypertension: A New Phenotype?

Yochai Adir, MD, FCCP; Robert Shachner, MD; Offer Amir, MD; Marc Humbert, MD, PhD
Author and Funding Information

From the Pulmonary Division (Dr Adir), the Radiology Division (Dr Shachner), and the Cardiology Division (Dr Amir), Carmel Medical Center, Faculty of Medicine, The Technion, Institute of Technology, Haifa, Israel; Université Paris-Sud (Dr Humbert), Faculté de Médecine, Le Kremlin-Bicêtre; Assistance Publique Hôpitaux de Paris (Dr Humbert), Service de Pneumologie, Hôpital Bicêtre, Le Kremlin-Bicêtre; and Institut National de la Santé et de la Recherche Médicale (Inserm) U999 (Dr Humbert), Centre Chirurgical Marie Lannelongue, Le Plessis-Robinson, France.

Correspondence to: Yochai Adir, MD, FCCP, Pulmonary Division, Carmel Medical Center, 7 Michal St, Haifa, Israel; e-mail: adir-sh@zahav.net.il


Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2012;142(6):1654-1658. doi:10.1378/chest.11-2816
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Mild to moderate precapillary pulmonary hypertension (PH) is a common complication of COPD and has typically been related to severe airflow limitation associated with chronic hypoxemia. Previous studies focusing specifically on patients with emphysema found that worsening PH was associated with progression of airflow obstruction. In the present report, we describe a new phenotype of COPD with severe precapillary PH in patients presenting with progressive dyspnea, normal spirometry, severely reduced diffusion capacity of the lung for carbon monoxide, and high-resolution CT scans of the chest showing diffuse centrilobular emphysema.

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