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Serial Testing With TB Interferon-γ Release AssaysSerial Testing With Interferon-χ Release Assays: Toward a Nuanced Understanding

Madhukar Pai, MD, PhD
Author and Funding Information

From the Department of Epidemiology and Biostatistics, McGill University, and Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute.

Correspondence to: Madhukar Pai, MD, PhD, Department of Epidemiology and Biostatistics, McGill University, 1020 Pine Ave W, Montreal, QC, H3A 1A2, Canada; e-mail: madhukar.pai@mcgill.ca


Financial/nonfinancial disclosures: The author has reported to CHEST that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.

Funding/Support: The author is supported by the Canadian Institutes of Health Research [Grant MOP-81362] and the European and Developing Countries Clinical Trials Partnership (EDCTP) [Grant TB-NEAT].

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2012;142(6):1366-1367. doi:10.1378/chest.12-1208
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Extract

Few tests for TB can boast of an evidence base that is as rich as that for interferon-γ release assays (IGRAs) for latent TB infection (LTBI).1-4 Although the dust has largely settled on their utility as screening tests for LTBI, data are now emerging thick and fast on their performance in serial testing both from research studies and from hospital infection control programs that routinely use IGRAs for serial testing of employees.5-8

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