Sedative and analgesic drugs are used routinely on patients in the ICU who are mechanically ventilated. These drugs can be administered either by continuous infusion or by intermittent IV bolus strategies. The theoretical benefit of a continuous infusion strategy is maintenance of a constant level of drug, leading to improved patient comfort. This strategy is also less taxing on the busy bedside nurse. The potential detriments include a tendency to use more drug(s), which may result in heavier levels of sedation. The theoretical benefit of an intermittent bolus strategy is a reduction in the drug amount used and a lesser tendency to oversedate patients; however, this approach may lead to a lower level of patient comfort and a greater burden on the bedside nursing staff. This editorial debate presents an evidence-based summary, highlighting the superiority of the continuous infusion strategy.