SESSION TYPE: Tobacco Cessation and Prevention
PRESENTED ON: Tuesday, October 23, 2012 at 04:30 PM - 05:45 PM
PURPOSE: To ascertain differences in health related quality of life among lung cancer screening study participants with significant smoking history.
METHODS: 4000 individuals aged 50-79 years participated in PLuSS, a CT-based lung cancer screening study. Subsequently, 977 subjects at the highest lung cancer risk stratum were enrolled into PLuSS-extension. 96% were white and 58.5% were men. Subjects were distributed by age in the following manner: 15% 50-59 years, 24% 60-64 years, 30% 65-69 years and 31% 70 years or greater. 27.8%, 37.5% and 34.7% of subjects attained high school or less, some college and college degree or higher respectively. Similarly, 20%, 48% and 22% smoked less than 20, 20-29 and 30 or more cigarettes per day respectively. 55.5% of subjects were current smokers at PLuSS-extension enrollment. All 977 participants were assessed using spirometry, St. George’s Respiratory Questionnaire (SGRQ) and the MRC dyspnea scale. 12 subjects were excluded due to missing data. Differences in mean SGRQ scores were tested using the Kruskal-Wallis chi-square test.
RESULTS: Females reported higher levels of impairment on activity (p<0.0001), impact (p=0.0375) and total scores (p=0.0010). No gender difference was detected in symptom domain (p=0.2400). Age was not associated with differences in any SGRQ scores. Educational attainment was inversely associated with impairment in activity (p=0.0021), impact (p=0.0064) and total scores (p=0.0028). Level of attained education was not associated with symptom scores (p=0.1014). Current smoking was associated with impairments in symptom (p<0.0001) impact (p=0.0216) and total score domains (p=0.0112). There was no association between current smoking and activity scores (p=0.7701). Number of cigarettes smoked per day was associated with impairment on all SGRQ scores. Spirometry-based GOLD scores and MRC dyspnea grades both showed strong statistical association with all SGRQ domains (p<0.0001).
CONCLUSIONS: In a population with significant smoking history, we found varying levels of HRQL-impairment on the basis of education, gender, smoking status and number of cigarettes consumed per day.
CLINICAL IMPLICATIONS: This finding may assist in clinical assessment and care of non-hospitalized smokers.
DISCLOSURE: The following authors have nothing to disclose: Chimeremma Nnadi, Joel Weissfeld
No Product/Research Disclosure InformationDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA