Disorders of the Pleura |

Incidence of Infection Among Patients on Chemotherapy With Tunneled Indwelling Pleural Catheters FREE TO VIEW

Essam Mekhaiel*, MD; Rahul Kashyap, MBBS; Fabien Maldonado, MD; John Mullon, MD
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Mayo Clinic College of Medicine, Rochester, MN

Chest. 2012;142(4_MeetingAbstracts):523A. doi:10.1378/chest.1390769
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SESSION TYPE: Pleural Disease Posters

PRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PM

PURPOSE: Tunneled indwelling pleural catheters (IPC) are a United States Food and Drug Administration-approved implantable device used for palliation of recurrent, symptomatic malignant pleural effusions. Although complication rates are low concern remains for increased infections due to this device in the setting of chemotherapy. We report our experience with infectious complications from the use of IPCs in those patients receiving concurrent chemotherapy.

METHODS: The study includes retrospective chart review of little over 5 years of patients with Tunneled indwelling pleural catheters (IPC). A total of 259, patients with first time insertion of IPC were included in analysis. All patient had research authorization provided in medical records. Study was approved by Institutional Review Board.

RESULTS: Out of 259 the catheter placement was as follows: 128 (49%) right sided, 122 (47%) left and 9 (4%) bilateral. In this cohort a total of 20 (7.7%) patients developed infection. Out of these 11 (55%) had Cellulitis and 9 (45%) had Empyema. Median catheter duration (N=109 patients) was 72 days (IQR= 27.5 -146). A total of 14 (9.1%) patients out of 154, who received chemotherapy had infection vs. 6 (6.2%) patients, out of 97, who didn’t receive chemotherapy developed infection (p=0.4).

CONCLUSIONS: Overall risk of infection in patient with Tunneled indwelling pleural catheters is mediocre, the risk of serious infection as Empyema is even lower. Being on Chemotherapy doesn’t cause additional risk for infection in such patients.

CLINICAL IMPLICATIONS: Every thirteenth patient, who get tunneled indwelling pleural catheters (IPC) placement, is likely to have an infection either cellulitis or empyema. Chemotherapy shouldn’t be seen as a contraindication for IPC insertion.

DISCLOSURE: The following authors have nothing to disclose: Essam Mekhaiel, Rahul Kashyap, Fabien Maldonado, John Mullon

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Mayo Clinic College of Medicine, Rochester, MN




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