0
Diffuse Lung Disease |

Clinical and Hemodynamic Features of Patients With Sarcoidosis-Associated Pulmonary Hypertension

Harris Tesher*, MD; Ellen-Marie Kenny, NP; Ajith Nair, MD; Sakshi Dua, MD
Author and Funding Information

Mount Sinai Hospital, New York, NY


Chest. 2012;142(4_MeetingAbstracts):447A. doi:10.1378/chest.1390763
Text Size: A A A
Published online

Abstract

SESSION TYPE: ILD Posters

PRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PM

PURPOSE: Sarcoidosis Associated Pulmonary Hypertension (SAPH) is known to be a heterogeneous disease with varied pathologic mechanisms. We sought to identify the clinical and hemodynamic characteristics that are unique to SAPH.

METHODS: A retrospective chart review was conducted on 53 sarcoidosis patients identified as having pulmonary hypertension (PH) via transthoracic echocardiogram (TTE). Clinical variables and hemodynamics obtained during right heart catheterization (RHC) were collected.

RESULTS: 81% of patients diagnosed with PH by TTE underwent RHC. PH was confirmed in 73% of those patients, of which 30% had pulmonary capillary wedge pressure (PCWP) >15 mmHg reflecting pulmonary venous hypertension. Among the patients with PH who underwent vasoreactivity testing with inhaled nitric oxide, 21% had a positive result. Among all patients diagnosed with PH by TTE, 49% had other diagnoses that may contribute to PH, including venous thromboembolism, obstructive sleep apnea, chronic obstructive pulmonary disease, left ventricular dysfunction and human immune-deficiency virus infection.

CONCLUSIONS: The presence of co-morbid conditions known to contribute to PH was observed in nearly half of patients with SAPH, and one-third of patients had pulmonary venous hypertension.

CLINICAL IMPLICATIONS: Careful evaluation and treatment of co-existing conditions contributing to SAPH is therefore necessary prior to initiating PH-specific therapies.

DISCLOSURE: The following authors have nothing to disclose: Harris Tesher, Ellen-Marie Kenny, Ajith Nair, Sakshi Dua

No Product/Research Disclosure Information

Mount Sinai Hospital, New York, NY

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543