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Clinical and Hemodynamic Features of Patients With Sarcoidosis-Associated Pulmonary Hypertension FREE TO VIEW

Harris Tesher*, MD; Ellen-Marie Kenny, NP; Ajith Nair, MD; Sakshi Dua, MD
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Mount Sinai Hospital, New York, NY

Chest. 2012;142(4_MeetingAbstracts):447A. doi:10.1378/chest.1390763
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PRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PM

PURPOSE: Sarcoidosis Associated Pulmonary Hypertension (SAPH) is known to be a heterogeneous disease with varied pathologic mechanisms. We sought to identify the clinical and hemodynamic characteristics that are unique to SAPH.

METHODS: A retrospective chart review was conducted on 53 sarcoidosis patients identified as having pulmonary hypertension (PH) via transthoracic echocardiogram (TTE). Clinical variables and hemodynamics obtained during right heart catheterization (RHC) were collected.

RESULTS: 81% of patients diagnosed with PH by TTE underwent RHC. PH was confirmed in 73% of those patients, of which 30% had pulmonary capillary wedge pressure (PCWP) >15 mmHg reflecting pulmonary venous hypertension. Among the patients with PH who underwent vasoreactivity testing with inhaled nitric oxide, 21% had a positive result. Among all patients diagnosed with PH by TTE, 49% had other diagnoses that may contribute to PH, including venous thromboembolism, obstructive sleep apnea, chronic obstructive pulmonary disease, left ventricular dysfunction and human immune-deficiency virus infection.

CONCLUSIONS: The presence of co-morbid conditions known to contribute to PH was observed in nearly half of patients with SAPH, and one-third of patients had pulmonary venous hypertension.

CLINICAL IMPLICATIONS: Careful evaluation and treatment of co-existing conditions contributing to SAPH is therefore necessary prior to initiating PH-specific therapies.

DISCLOSURE: The following authors have nothing to disclose: Harris Tesher, Ellen-Marie Kenny, Ajith Nair, Sakshi Dua

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Mount Sinai Hospital, New York, NY




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