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Procalcitonin as a Predictor of Bacteremia and Prognosis in Severe Sepsis FREE TO VIEW

Jung Ar Shin, MD; Sang Young Kim*, MD; Chul Min Ahn, MD; Min Kwang Byun, MD
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Yonsei University College of Medicine, Seoul, Republic of Korea

Chest. 2012;142(4_MeetingAbstracts):287A. doi:10.1378/chest.1390715
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SESSION TYPE: Sepsis/Shock

PRESENTED ON: Sunday, October 21, 2012 at 11:30 AM - 11:45 AM

PURPOSE: This study aimed to evaluate the usefulness of procalcitonin (PCT) as a predictor for bacteremia and prognosis in severe sepsis.

METHODS: We analyzed the medical records of 148 patients who presented with severe sepsis defined by the American College of Chest Physicians/Society of Critical Care Medicine (ACCP/SCCM) Consensus Conference definitions, at Gangnam Severance Hospital, a tertiary referral medical center in Seoul, Korea.

RESULTS: Of 148 patients, 77 patients (52.0%) had bacteremia. The median age was 67.5 years (range, 17-90 years) and 94 (63.5%) were male. Baseline characteristics and other inflammatory markers including C-reactive protein and delta neutrophil counts showed no significant difference between bacteremia and non-bacteremia groups. PCT showed no significant difference according to the type of infection. Bacteremia group showed significantly higher PCT (1.68, range 0.07-100.00) than non-bacteremia group (0.32, range 0.00-107.16) (p=0.032). With a cut-off value of 0.5 ng/ml, PCT was the meaningful predictor for death (OR 2.878 (1.367-6.058), p=0.005), as well as for bacteremia (OR 2.879 (1.459-5.681), p=0.002).

CONCLUSIONS: Procalcitonin is a useful marker to predict bacteremia and prognosis in severe sepsis.

CLINICAL IMPLICATIONS: Biomarker for prognosis of severe sepsis

DISCLOSURE: The following authors have nothing to disclose: Jung Ar Shin, Sang Young Kim, Chul Min Ahn, Min Kwang Byun

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Yonsei University College of Medicine, Seoul, Republic of Korea




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