SESSION TYPE: Cystic Fibrosis/ Bronchiectasis Posters
PRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PM
PURPOSE: Fungi are frequently identified on routine sputum cultures in patients with noncystic fibrosis (nonCF) bronchiectasis but the pathologic significance of these organisms is unclear. The purpose of this investigation is to determine if the presence of fungi correlates with markers of disease severity.
METHODS: Microbiological results of sputum and bronchoalveolar lavage samples from 132 patients with CT scan confirmed bronchiectasis were reviewed. Patients with allergic bronchopulmonary aspergillosis and CF were excluded. Demographics, smoking history, lung function, and Pseudomonas presence were compared in patients with and without sputum fungi using Fisher’s exact tests.
RESULTS: 71 (53.8%) patients produced sputum containing a fungus. Candida was the most commonly identified genus, seen in 52 patients, followed by Aspergillus in 19 patients. Age, gender, smoking history, presence of Pseudomonas, and lung function did not differ significantly between the two groups.
CONCLUSIONS: Fungi are present in the majority of sputum samples produced by patients with nonCF bronchiectasis. The presence of these organisms does not correlate with markers of disease severity.
CLINICAL IMPLICATIONS: It appears that the presence of fungi on routine sputum cultures does not have pathological significance. Future studies examining the effect of fungi on quality of life and lung function over time are indicated.
DISCLOSURE: The following authors have nothing to disclose: Pamela McShane, Edward Naureckas, Steven White, Mary Strek
No Product/Research Disclosure InformationUniversity of Chicago, Chicago, IL