Diffuse Lung Disease |

Vitamin D Insufficiency Is Associated With Decline in Lung Function and Diffusion Capacity in Connective Tissue Related Interstitial Lung Disease FREE TO VIEW

Emilia Anigbo*, MD; Mehdi Khosravi, MD
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University of Kentucky, Lexington, KY

Chest. 2012;142(4_MeetingAbstracts):442A. doi:10.1378/chest.1390322
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PRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PM

PURPOSE: We investigated the relationship between Vitamin D levels and lung function in patients with connective tissue related ILD and hypothesized that lower vitamin D levels would be associated with reduced forced Vital capacity (FVC), total lung capacity (TLC) and diffusion lung capacity (DLCO).

METHODS: A Retrospective chart review of outpatient records of patients from rheumatology and pulmonary clinics in the UK healthcare system was done. Twenty one patients from both clinics with connective tissue related ILD were identified for the study. The outpatient charts and medical records were reviewed to obtain their vitamin D levels, spirometry and full PFTs from April 2009 to September 2011.

RESULTS: Overall prevalence of vitamin D deficiency and insufficiency were 16 and 58 percent, respectively. Diminished FVC (r=0.53), TLC (r=0.46) and DLCO (r=0.60) correlated with lower levels of vitamin D (p values of 0.004, 0.02 and 0.003, respectively)

CONCLUSIONS: There is a high prevalence of vitamin D insufficiency in patients with connective tissue related-ILD. The vitamin D levels are correlated with reduced TLC, FVC and DLCO.

CLINICAL IMPLICATIONS: Vitamin D insufficiency may play a role in lung manifestations of connective tissue disease.

DISCLOSURE: The following authors have nothing to disclose: Emilia Anigbo, Mehdi Khosravi

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University of Kentucky, Lexington, KY




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