SESSION TYPE: Physiology/PFTs/ Rehabilitation Posters
PRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PM
PURPOSE: Exposure to secondhand smoke (SHS) is a significant threat to personal, occupational and public health. Research has indicated that exposure to SHS within a car or bar can lead to very potent levels of exposure, with particulate matter smaller than 2.5 microns (PM2.5), commonly used as a marker of exposure. With the above in mind the purpose of this study was to assess how different levels of short term exposure to SHS may induce a change is respiratory flow resistance and pulmonary oxidative stress.
METHODS: After written informed consent, participants (n=15) were exposed for 20 minutes to SHS exposure at a PM2.5 concentration of 500 μg/m3 within an exposure chamber (simulating exposure in a moving car with limited ventilation, or in a smoke filled bar). The participants’ total respiratory impedance (Z5Hz), resistances (at R5Hz, R10Hz, R20Hz) and reactance (X5Hz, X10Hz, X20Hz) were measured with the use of an impulse osscilometry (IOS) system. Analysis was performed with SPSS 20.
RESULTS: Short term exposure to SHS at these concentrations was found to have a significant impact on the subjects airway impedance (Z5Hz), which was found to increase by 0.037[kPa/(L/s), and as also was airway resistance at R5Hz by 0.034[kPa/(L/s)], at R10Hz by 0.036[kPa/(L/s)] and at R20Hz by 0.039[kPa/(L/s)] respectively. In all cases a p<0.01 was noted. Overall central airway resistance was also found to increase by 0.028[kPa/(L/s)], as was peripheral airway resistance by 0.037[kPa/(L/s)], albeit non statistically significantly (p=0.054 and p=0.102, respectively)
CONCLUSIONS: Short term exposure to SHS at bar or car levels of exposure lead to immediate adverse changes in pulmonary mechanics, inducing airway restriction over a number of frequencies. While the above results are promising, further research is needed to assess the impact of SHS exposure on overall airway resistance with a larger study population.
CLINICAL IMPLICATIONS: These findings may indicate an additional mechanistic link between SHS exposure and the development of pulmonary disease.
DISCLOSURE: The following authors have nothing to disclose: Hara Stathopoulou, Constantine Vardavas, Vassiliki Evangelopoulou, Anna Tzwrtzi, Gregory Connolly, Panagiotis Behrakis
No Product/Research Disclosure InformationSmoking and Lung Cancer Research Center, Hellenic Cancer Society, Athens, Greece