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Histologic Characterization of Lung Cancer and Other Solid Tumors With Tissue Obtained by Bronchoscopy Guided by Endobronchial Ultrasound Transbronchial Needle Aspiration FREE TO VIEW

Humberto Choi*, MD; Jennifer Brainard, MD; Duc Ha, MD; Wissam Jaber, MD; Fadi Abdul-Karim, MD; Christine Booth, MD; Deborah Chute, MD; Joseph Cicenia, MD; Thomas Gildea, MD; Abha Goyal, MD; Gregory Kotnis, MD; Michael Machuzak, MD; Peter Mazzone, MD; Jinesh Patel, MD; Jordan Reynolds, MD; Francisco Almeida, MD
Author and Funding Information

Cleveland Clinic Foundation - Respiratory Institute, Cleveland, OH

Chest. 2012;142(4_MeetingAbstracts):636A. doi:10.1378/chest.1390104
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SESSION TYPE: Lung Cancer Posters I

PRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PM

PURPOSE: Bronchoscopy guided by endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive procedure that is safe and has a high diagnostic yield for tissue diagnosis and mediastinal staging in patients with non-small cell lung cancer (NSCLC). The purpose of this study is to evaluate the adequacy of tissue samples obtained by EBUS-TBNA for histologic characterization of lung cancer and other solid cancers.

METHODS: We retrospectively analyzed consecutive patients who underwent EBUS-TBNA for either diagnosis of mediastinal and hilar lymphadenopathy or for diagnosis and/or mediastinal staging of confirmed or suspected lung cancer. In those proven to have a primary lung cancer or other solid tumor by tissue obtained during the EBUS-TBNA, the adequacy of the tissue for a specific histological subtype was recorded.

RESULTS: One hundred and forty EBUS-TBNA cases resulted in a diagnosis of lung cancer or other solid tumor. The tissue obtained was considered adequate for histologic classification in all 140 fine needle aspiration specimens. Sixty six (47.1%) were men and mean age was 64.9+10.7 years. One hundred and thirty (92.8%) patients had a specific histologic subtype characterization of tumor. Seventy two (51.4%) were diagnosed with adenocarcinoma, 23 (16.4%) with squamous cell carcinoma, and 20 (14.2%) with small cell lung cancer. Ten (8.1%) were diagnosed with non-small cell carcinoma with no specific characterization.

CONCLUSIONS: Diagnostic specimens from metastatic mediastinal and hilar lymph nodes obtained by EBUS-TBNA are usually adequate for accurate histological subtyping of solid tumors.

CLINICAL IMPLICATIONS: Diagnostic specimens obtained by EBUS-TBNA are generally adequate for specific histological subtyping. This is of major importance when defining non-small cell lung cancer therapy.

DISCLOSURE: The following authors have nothing to disclose: Humberto Choi, Jennifer Brainard, Duc Ha, Wissam Jaber, Fadi Abdul-Karim, Christine Booth, Deborah Chute, Joseph Cicenia, Thomas Gildea, Abha Goyal, Gregory Kotnis, Michael Machuzak, Peter Mazzone, Jinesh Patel, Jordan Reynolds, Francisco Almeida

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Cleveland Clinic Foundation - Respiratory Institute, Cleveland, OH




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