SESSION TYPE: Lung Cancer Posters I
PRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PM
PURPOSE: Bronchoscopy guided by endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive procedure that is safe and has a high diagnostic yield for tissue diagnosis and mediastinal staging in patients with non-small cell lung cancer (NSCLC). The purpose of this study is to evaluate the adequacy of tissue samples obtained by EBUS-TBNA for histologic characterization of lung cancer and other solid cancers.
METHODS: We retrospectively analyzed consecutive patients who underwent EBUS-TBNA for either diagnosis of mediastinal and hilar lymphadenopathy or for diagnosis and/or mediastinal staging of confirmed or suspected lung cancer. In those proven to have a primary lung cancer or other solid tumor by tissue obtained during the EBUS-TBNA, the adequacy of the tissue for a specific histological subtype was recorded.
RESULTS: One hundred and forty EBUS-TBNA cases resulted in a diagnosis of lung cancer or other solid tumor. The tissue obtained was considered adequate for histologic classification in all 140 fine needle aspiration specimens. Sixty six (47.1%) were men and mean age was 64.9+10.7 years. One hundred and thirty (92.8%) patients had a specific histologic subtype characterization of tumor. Seventy two (51.4%) were diagnosed with adenocarcinoma, 23 (16.4%) with squamous cell carcinoma, and 20 (14.2%) with small cell lung cancer. Ten (8.1%) were diagnosed with non-small cell carcinoma with no specific characterization.
CONCLUSIONS: Diagnostic specimens from metastatic mediastinal and hilar lymph nodes obtained by EBUS-TBNA are usually adequate for accurate histological subtyping of solid tumors.
CLINICAL IMPLICATIONS: Diagnostic specimens obtained by EBUS-TBNA are generally adequate for specific histological subtyping. This is of major importance when defining non-small cell lung cancer therapy.
DISCLOSURE: The following authors have nothing to disclose: Humberto Choi, Jennifer Brainard, Duc Ha, Wissam Jaber, Fadi Abdul-Karim, Christine Booth, Deborah Chute, Joseph Cicenia, Thomas Gildea, Abha Goyal, Gregory Kotnis, Michael Machuzak, Peter Mazzone, Jinesh Patel, Jordan Reynolds, Francisco Almeida
No Product/Research Disclosure InformationCleveland Clinic Foundation - Respiratory Institute, Cleveland, OH