SESSION TYPE: ILD - Bench to Bedside
PRESENTED ON: Wednesday, October 24, 2012 at 02:45 PM - 04:15 PM
PURPOSE: Poor sleep, non-restorative sleep, fatigue and hypersomnolence are quite common in sarcoidosis patients. The etiology for these complaints is likely multifactorial and may include disorders such as obstructive sleep apnea syndrome (OSAS). The purpose of our study was to evaluate the prevalence of OSAS in Sarcoidosis patients
METHODS: We evaluated all patients who were given the ICD-9 code 135.0 and were seen at the Medical University of South Carolina (MUSC) Sarcoidosis Clinic from 2000-2011. From these individuals (n = 5079) and the 4066 sleep studies performed in the MUSC sleep laboratory, we could consecutively evaluate sleep studies from 2008-2011. OSAS was defined by a respiratory disturbance index (RDI) >5/hour. Statistics were performed in JMP and p-values <0.05 were considered significant.
RESULTS: From 2008-2011, 73 consecutive patients with sarcoidosis had one or more sleep studies performed. The patients consisted of 11 men and 62 women with a mean age of 51.1 ± 9.6 years. Mean BMI was 37.5 ± 9.8 (range 19-75.8). Mean sleep efficiency was similar between patients on prednisone (80.2 ± 13.3%, n=34) and those who were not on prednisone (78.4 ± 11.2%, n=34); (p=NS). Patients using prednisone had a mean RDI of 24.7 ± 28.6 and those not using prednisone had a mean RDI of 19.0 ± 22.0 (P = NS). OSAS was diagnosed in 59 of 71 (83%) of sarcoidosis patients. Oxygen saturation during sleep showed no association with FVC or FEV1 but was associated with RDI (R2= 0.22, P<0.001) and BMI (R2=0.1, p<0.01).
CONCLUSIONS: Sarcoidosis patients who received sleep studies at MUSC have a high prevalence of OSAS. Most of the prevalence in our study was associated with traditional risk factors for OSAS.
CLINICAL IMPLICATIONS: Further studies should define whether the risk for OSAS in sarcoidosis patients is independent of obesity.
DISCLOSURE: The following authors have nothing to disclose: Chitra Lal, Heidi Grund, Charlie Strange
No Product/Research Disclosure InformationMedical University of South Carolina, Charleston, SC