0
Signs and Symptoms of Chest Diseases |

Differentiation of IPF From NSIP by Cytokine Profiling

Anthony Loria*, BS; Lei Wang, MS; Mary Smith, BS; Anne Brown, MD; Oksana Shlobin, MD; Steven Nathan, MD
Author and Funding Information

Inova Advanced Lung Disease and Transplant Program, Department of Medicine, Inova Fairfax Hospital, Falls Church, VA


Chest. 2012;142(4_MeetingAbstracts):957A. doi:10.1378/chest.1390055
Text Size: A A A
Published online

Abstract

SESSION TYPE: New Insights into Idiopathic Pulmonary Fibrosis

PRESENTED ON: Sunday, October 21, 2012 at 01:15 PM - 02:45 PM

PURPOSE: The differentiation of NSIP from IPF often requires a surgical lung biopsy. Cytokines, characteristic of fibrosis and inflammation, have been identified as potential markers of disease progression in both IPF and NSIP. Here we aimed to determine the viability of using cytokine profiles in differentiating the diagnosis of NSIP from IPF.

METHODS: Patients with IPF or NSIP seen and diagnosed by standard criteria within an Advanced Lung Diseases Clinic were identified. Fasting blood was collected to measure levels of 20 cytokines via Bio-Plex Suspension Array System (Bio-Rad Laboratories, Inc., Hercules, CA). Mann-Whitney U test was performed to determine statistically different levels of cytokines between disease groups. Based on this, variables were selected for logistic regression and ROC curve generation.

RESULTS: Data from 35 patients were obtained and analyzed. Of these, 20 had IPF and 15 NSIP. There were 12 females and the mean age of the group was 62 ± 9 years. Significant differences in levels between IPF and NSIP patients were noted for: TGF-b1 (Z -2.37, p=.018) and IP-10 (Z -2.33, p=.019), while TNF-a trended toward significance (Z-1.82, p=.069). Aforementioned variables were incorporated in a logistic forward conditional regression model to predict NSIP. The significant predictors of diagnosis were TGF-b1 and TNF-a [AUC=0.78 (95% CI=0.63- 0.94), p=.003].

CONCLUSIONS: Despite being preliminary, our promising results suggest that mathematical modeling exploiting different pathogenic pathways or consequences of these diseases may prove to be a viable diagnostic approach.

CLINICAL IMPLICATIONS: Recognition and determination of different cytokine patterns of expression may enable the non-invasive differentiation of NSIP from IPF.

DISCLOSURE: The following authors have nothing to disclose: Anthony Loria, Lei Wang, Mary Smith, Anne Brown, Oksana Shlobin, Steven Nathan

No Product/Research Disclosure Information

Inova Advanced Lung Disease and Transplant Program, Department of Medicine, Inova Fairfax Hospital, Falls Church, VA

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543