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Diffuse Lung Disease |

The Utility of Pulmonary PET Activity and CT Findings in Sarcoidosis

Jelica Videnovic-Ivanov*, PhD; Dragana Sobic-Saranovic, PhD; Violeta Vucinic, PhD; Isidora Grozdic, MD; Snezana Filipovic, MD; Maja Omcikus, MD; Vlada Zugic, PhD
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Clinic for Lung Diseases and Tuberculosis, CC Serbia, Belgrade, Serbia


Chest. 2012;142(4_MeetingAbstracts):440A. doi:10.1378/chest.1389993
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Abstract

SESSION TYPE: ILD Posters

PRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PM

PURPOSE: Sarcoidosis is systemic, granulomatous disorder of unknown etiology that predominantly affects the lung. Chest radiographic patterns are one of the first finding whether during the diagnostic or controlling period of the rest of sarcoidosis activity.The aim of this work is to analyse the role of whole body 18 F- fluorodeoxyglucosae positron emission tomography scans and CT in sarcoidosis with asses to differences between findings obtaining during, mentioned procedures.

METHODS: The analyse obtaine 57 patients ( mean ages 47.7 ±11.1, 21M / 36 F; acute phase : ACE 83.9 U/L UCa-2,35 in 14pts; chronic phase: ACE 52.3 U/L UCa -4.37 in 43 pts; pulmonary involvement in 34 pts while in 9 pts only nonpulmonary sarcoidsdis obtaine ) with previously histologically proven sarcoidosis.

RESULTS: The whole patients records such as medicals histories, blood serum analyses of sarcoidosis activity, clinical symptoms and signs,lung function tests,radiographic findings are included in this analyse.Positive PET scans finding are in 53/57patients while positive CT findings were in 50/57 patients. In 35/53 patients, positive PET scan is manifesting in the pulmonary parenchyma.Diffusing capacity for carbon monoxide is lower in mentioned patients ( 62. ± 7 18.1 predicted versus patients without lung parenchymal PET positivity 85.3± 15.1% predicted ). At the same time, Chest radiographic patterns are as followed: I radiographic stage-8 pts, II radiographic stage-5 pts, III radiographic stage 25 pts and IV radiographic stage -5 pts.In 41/57 patients the higher level of SUV is notify in lymph nodes while on CT findings enlargament of lymph nodes obtaine in 45/53 patients.

CONCLUSIONS: The results of this analyse obtaine the Impact and importance of FDG/PET scan as additional diagnostic tests along with standard radiographic and CT scan. Radiographic chest changes established by standard radiography and CT features were associated with lung parenchimal and lymphadenopathy PET positivity in most patients.

CLINICAL IMPLICATIONS: Those diagnostic tools, PET / CT findings can have the additional impact on patients management and therapies modalities.

DISCLOSURE: The following authors have nothing to disclose: Jelica Videnovic-Ivanov, Dragana Sobic-Saranovic, Violeta Vucinic, Isidora Grozdic, Snezana Filipovic, Maja Omcikus, Vlada Zugic

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Clinic for Lung Diseases and Tuberculosis, CC Serbia, Belgrade, Serbia

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