SESSION TYPE: ICU Safety and Quality Posters
PRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PM
PURPOSE: To study the relationship between alcohol use and serum 25-hydroxyvitamin D (25(OH)D) concentration at admission to the medical ICU.
METHODS: This is a prospective observational study of all admissions to the medical ICU at Grady Memorial Hospital (Atlanta, GA) from November 11, 2011 to March 8, 2012. We excluded those < 18 years of age and those with an anticipated ICU stay < 1 day. Clinical data was collected from the electronic medical record and phlebotomy was performed on all patients with informed consent. Serum 25(OH)D was assayed using an automated chemiluminescent technique. The Alcohol Use Disorders Identification Test (AUDIT) was administered to patients or their surrogates during admission and hazardous drinking was defined as a score ≥ 8.
RESULTS: Fifty-three patients with serum 25(OH)D measurements and completed AUDITs were included in the study. The group was predominantly black (83.0%), with 52.8% male, a median age of 56 (IQR 47-62) and median APACHE II of 21.5 (IQR 15-28). Median AUDIT score was 1, with 5 subjects (9.4%) with a score ≥ 8. Serum 25(OH)D concentrations were non-significantly lower in those with an AUDIT score > 8 (11.7 ng/mL vs. 14.7 ng/mL, p=0.57). Increasing AUDIT score was also non-significantly correlated with decreasing serum 25(OH)D in a univariate linear model (β = -0.26, p= 0.49).
CONCLUSIONS: Serum 25(OH)D concentrations were universally low in this sample of adult medical ICU patients and the frequency of hazardous drinking was also low. While 25(OH)D concentration was lower among hazardous drinking, more data needs to be gathered to determine the association between alcohol use and vitamin D status.
CLINICAL IMPLICATIONS: The association of hazardous alcohol drinking with serum 25(OH)D in adult medical ICU patients needs further study.
DISCLOSURE: The following authors have nothing to disclose: Kathyn West, Jordan Kempker, Thomas Ziegler, Vin Tangpricha, David Guidot, Greg Martin
No Product/Research Disclosure InformationEmory University SOM, Decatur, GA