Pulmonary Physiology |

Lung Function Decline and Predictors in Older People From the English Longitudinal Study of Aging FREE TO VIEW

Abebaw Yohannes*, PhD; Gindo Tampubolon, PhD
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Manchester Metropolitan University, Manchester, United Kingdom

Chest. 2012;142(4_MeetingAbstracts):784A. doi:10.1378/chest.1389785
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SESSION TYPE: Physiology/PFTs/ Rehabilitation I

PRESENTED ON: Sunday, October 21, 2012 at 01:15 PM - 02:45 PM

PURPOSE: Lung function declines with age. However, the rate of decline in forced expiratory volume in 1 second (FEV1), in the healthy population and predictors of this change in elderly community-dwellers without established disease is unknown.

METHODS: We analysed data from 4656 adult participants aged 50 years and older from the English Longitudinal Study of Ageing, with full spirometry, in four years follow-up. A random-coefficient model was used to assess potential predictors of both FEV1 and their changes over time.

RESULTS: The mean (±SE) rate of change in FEV1 was a decline of 47± 14 ml per year and 95% confidence interval [CI, 20 to 74]. The rate of decline in mean FEV1 in smokers was 299 ml per year [CI, 238 to 339] compared to non-smokers. Participants with cardiovascular disease had decline in mean FEV1 was 45 ml per year [CI, 11 to 79], history of breathlessness using the Medical Research Council scale was 78 ml per year [CI, 61 to 95] and history of phlegm was 85 ml per year [CI 42 to 128]. Participants with self-reported good health have increased in mean FEV1 92 ml per year [CI 54 to 128] compared to poorer health status and those with high haemoglobin with greater FEV1 6 ml per year [CI, 1 to 11] compared with low haemoglobin. In addition, participants with low C-reactive protein showed a decline in mean FEV1 by 5 ml per year [CI, 3 to 7] and low in Fibrinogen count showed a decline in mean FEV1 by 2 ml per year (not statistically significant) [CI, 28 to -24].

CONCLUSIONS: The rate of decline in FEV1 in elderly healthy participants was high, with increased rates of decline in current smokers, those with history of breathlessness and mucous secretion.

CLINICAL IMPLICATIONS: The rate of lung function decline in older people without established lung disease was very high. Current smokers should be advised to stop smoking and attend smoking cessation class in the community.

DISCLOSURE: The following authors have nothing to disclose: Abebaw Yohannes, Gindo Tampubolon

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Manchester Metropolitan University, Manchester, United Kingdom




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