Lung Cancer |

Potential of Angiopoietin-2 and VEGF as Serum Markers in Lung Cancer FREE TO VIEW

Rakesh Bhargava*, MD; Nafees Ahmad, MBBS; Zubair Ahmad, MD; Mohammad Owais, PhD
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J. N. Medical College, Aligarh, India

Chest. 2012;142(4_MeetingAbstracts):634A. doi:10.1378/chest.1389631
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SESSION TYPE: Lung Cancer Posters I

PRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PM

PURPOSE: 1- To study serum level of Angiopoietin-2 and its clinical implication in lung cancer patients 2-To study serum level of vascular endothelial growth factor and its relationship with Angiopoietin-2 in lung cancer patients

METHODS: Patients diagnosed with lung cancer by histologically who are aged above 35 years, without any co-morbid disease or malignancies and who have not taken any anti cancerous drugs were taken in the study. 90 patients were enrolled along with 30 control subjects Serum samples were taken after diagnosis.Qualitative and quantitative analysis of serum Angiopoietin-2and serum VEGF level was done by ELISA method using Quantikine human Angiopoietin-2 Immunoassay kit and VEGF 165 kit (Quantikine,human VEGF immune assay,R&D system)

RESULTS: Sensitivity and specificity of serum Angiopoietin-2 level in Lung cancer patients relative to control group were 95.6% and 54.3% ,respectively, at a cutoff value of 1015 pg/ml. Sensitivity and specificity of serum VEGF were 66.7% in Lung cancer &86.7% in control , at a cutoff value of 486 pg/ml .AUC for serum Angiopoietin-2 (0.935)was greater than for VEGF (0.870) Lung cancer patients had significant higher level of Angiopoietin-2 & VEGF and there level increases with stage progression. Serum Angiopoietin-2 was significantly positively correlated with VGEF

CONCLUSIONS: Patients with Lung cancer had significantly higher serum Angiopoietin-2 & VEGF levels than control group. In all patients with Lung cancer , there is a positive correlation between serum Angiopoietin-2 & VEGF

CLINICAL IMPLICATIONS: Angiopoietin-2 is a useful marker for evaluating Lung cancer specially distant metastasis in NSCLC. VEGF have significant prognostic Implication

DISCLOSURE: The following authors have nothing to disclose: Rakesh Bhargava, Nafees Ahmad, Zubair Ahmad, Mohammad Owais

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J. N. Medical College, Aligarh, India




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