Obstructive Lung Diseases |

Prevalence of Depressive Symptoms in Bronchitic and Nonbronchitic Phenotypes of COPD FREE TO VIEW

Vladimir Koblizek*, PhD; Sarka Pracharova; Miloslav Hronek, PhD; Miroslav Kovarik, PhD; Vladimir Palicka, PhD; Ladislava Pavlikova; Kamil Klenha; Petr Celakovsky, PhD; Jan Brozik; Jana Tuckova
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Pulmonary Department, University Hospital and Faculty of Medicine, Hradec Kralove, Czech Republic

Chest. 2012;142(4_MeetingAbstracts):720A. doi:10.1378/chest.1389379
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PRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PM

PURPOSE: Psychological sequelae of COPD may affect functional status independently of disease severity. Presence of depression among several phenotypes of COPD is not clearly understood. We wanted to find out the real occurrence of depression in both basic clinical phenotypes of COPD.

METHODS: Multicomponent assessment of 38 consecutive patients (6 females, 66,7 ± 7,6 years) with stable COPD (GOLD groups A 1, B 21, C O, D 16) in the out-patient clinic of university hospital (within non-interventional cross-sectional Complexity of COPD Study).

RESULTS: 27 patients had bronchitic and 11 subjects suffered from non-bronchitic phenotype of COPD (post- ipratropium and salbutamol FEV1 57,7%). Bronchitic variant was associated with lower level of depressive symptoms (Beck scale 5,1 ± 3 , Zung scale 50,2 ± 10,9) than that found in non-bronchitic subtype of COPD (Beck scale 8,3 ± 3,4, Zung scale 57.5 ± 7,4). Although this difference reached statistical significance only in Beck questionnaire p=0,013 (Mann Whitney test). In all other parameters (BMI, FFMI, education level, inhalation risk, 6MWD, exercise desaturation, mMRC dyspnea scale, Celli BODE, Puhan BODE, ADO, CAT, all domains of SGRQ, arterial blood gases, ECG heart rate) were no differences between these two basic phenotypes.

CONCLUSIONS: Non-bronchitic phenotype of COPD was associated with more depression complaints than bronchitic scenario. This difference was not apparent in terms of life quality, prognostic indices and number of other variables describing course of COPD.

CLINICAL IMPLICATIONS: Purposeful search for the presence of depressive symptoms is particularly important in patients with non-bronchitic phenotype of COPD.

DISCLOSURE: The following authors have nothing to disclose: Vladimir Koblizek, Sarka Pracharova, Miloslav Hronek, Miroslav Kovarik, Vladimir Palicka, Ladislava Pavlikova, Kamil Klenha, Petr Celakovsky, Jan Brozik, Jana Tuckova

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Pulmonary Department, University Hospital and Faculty of Medicine, Hradec Kralove, Czech Republic




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