Pulmonary Physiology |

The Effects of a Highly Portable Noninvasive Open Ventilation System Versus Standard Oxygen Therapy on Activities of Daily Living in Patients With Chronic Obstructive Pulmonary Disease FREE TO VIEW

Brian Carlin*, MD; Kim Wiles, RRT; Robert McCoy, RRT; Dan Easley, BS; Toni Brennan, RRT; Richard Morishige, RRT
Author and Funding Information

Sleep Medicine and Lung Health Consultants, Ingomar, PA

Chest. 2012;142(4_MeetingAbstracts):795A. doi:10.1378/chest.1389375
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SESSION TYPE: Physiology/PFTs/ Rehabilitation Posters

PRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PM

PURPOSE: This study evaluated the effects of traditional oxygen therapy versus non-invasive open ventilation (NIOV) therapy on activity of daily living (ADL) performance in patients in the home environment.

METHODS: Thirty patients with COPD were selected from an oxygen supplier's database and evaluated in an open-label, crossover, IRB approved in-home study. Inclusion criteria included supplemental oxygen use, elevated Borg dyspnea score, and the ability to perform ADLs. Patients were asked to perform a selected ADL using traditional oxygen therapy at their prescribed flow rate for as long as tolerable. A rest period was provided and patients were then asked to perform the same ADL using the NIOV system, again for as long as tolerated. SpO2 and Borg dyspnea scores were monitored and recorded throughout the entire study duration.

RESULTS: Mean (± SD) SpO2 for the oxygen therapy portion of the study was 90.7 (4.9) compared with 94.8 (2.0) for the NIOV portion of the study (p value <0.0001). The median Borg dyspnea score for ADLs using oxygen therapy was 3.0 versus 1.0 for the NIOV portion of the study (p value < 0.0001). NIOV therapy was well tolerated by all patients with general comments indicating that the device and nasal interface were comfortable to wear and made breathing easier.

CONCLUSIONS: NIOV use resulted in statistically and clinically significant improvements in oxygenation and dyspnea compared to traditional oxygen therapy during ADL performance in the home environment. Thus, NIOV therapy may provide a practical way to allow increased activities in patients who require supplemental oxygen.

CLINICAL IMPLICATIONS: Patients receiving long term oxygen therapy (LTOT) often experience dyspnea while performing activities of daily living (ADL) which may ultimately result in a reduced level of activity. Respiratory insufficiency is often a contributing factor to dyspnea while receiving LTOT. The novel non-invasive open ventilation (NIOV) device has been shown in this study to improve oxygenation and reduce dyspnea. This may ultimately allow an increase in exercise performance for patients with COPD who require supplemental oxygen therapy.

DISCLOSURE: Brian Carlin: Grant monies (from industry related sources): Grant money from Breathe Techonolgies

Kim Wiles: Employee: Klingensmith HealthCare

Robert McCoy: Grant monies (from industry related sources): Grant Money from Breathe Technologies

Dan Easley: Employee: Klingensmith HealthCare

Toni Brennan: Employee: Klingensmith HealtCare

Richard Morishige: Employee: Breathe Technologies

No Product/Research Disclosure Information

Sleep Medicine and Lung Health Consultants, Ingomar, PA




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