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Pulmonary Vascular Disease |

Screening for Connective Tissue Disease in Pulmonary Hypertension

Ricardo Pagan*, MD; Augustine Lee, MD; Charles Burger, MD
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Mayo Clinic Florida, Jacksonville, FL


Chest. 2012;142(4_MeetingAbstracts):816A. doi:10.1378/chest.1389270
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Abstract

SESSION TYPE: DVT/PE/Pulmonary Hypertension Posters I

PRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PM

PURPOSE: Connective tissue disease (CTD) has been associated with histological changes leading to the development of pulmonary arterial hypertension. Screening for CTD is very common in clinical practice, and is part of the diagnostic workup for suspected pulmonary hypertension (PH) as recommended by the ACC/AHA 2009 consensus guidelines (1). The aim of this study was to evaluate patients with pulmonary hypertension (PH) who underwent screening for CTD and compare to a group of patients without PH.

METHODS: Retrospective review of medical records on a subset of 140 patients evaluated in the PH Clinic at our institution from January, 2007 to November 2011 was used to record screening for anti-neutrophilic antibodies (ANA) and rheumatoid factor (RF). Data was compared to a group of 147 patients who were evaluated at the PH Clinic who did not have disease.

RESULTS: 61% of patients of the PH group were women, average age 58 (SD +/- 11) years. 46% were ANA positive and 26% were RF positive. 71% of the control (No PH) were women, average age 58 (SD +/-17), 47% were ANA positive and 18% were RF positive. 21% of patients were classified under the World Health Organization Diagnostic Group 1, 27% were group 2, 46% were group 3 and 4% group4. There was no statistical difference (P=0.4844, RR=1.11, 95%CI 0.8648 to 1.428) between patients with PH and without PH (95% CI: 0.4321 to 0.6164) or negative for (95% CI: 0.3818 to 0.5631) ANA. There was no statistical difference (P= 0.3192) when comparing patients with PH and without PH (95% CI: 0.2584 to 0.4498) or negative (95% CI: 0.1871 to 0.3753) for RF.

CONCLUSIONS: Screening for CTD with ANA/RF in patients with all types of PH did not show any difference when compared to patients without PH.

CLINICAL IMPLICATIONS: Clinical suspicion of the various co-morbidities associated with PH should be considered when deciding to screen PH patients for those diseases (2).

DISCLOSURE: The following authors have nothing to disclose: Ricardo Pagan, Augustine Lee, Charles Burger

No Product/Research Disclosure Information

Mayo Clinic Florida, Jacksonville, FL

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