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Epidemiology and Outcome of Sepsis and Nonsepsis Related Acute Kidney Injury (AKI) in Critically Ill Patients in Intensive Care Unit (ICU) of a Teaching Hospital in Jamshedpur, India FREE TO VIEW

Prakash Gore*, MD; Sanjay Srivastava, MD
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Tata Motors Hospital., Jamshedpur, India

Chest. 2012;142(4_MeetingAbstracts):396A. doi:10.1378/chest.1389134
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SESSION TYPE: Non Pulmonary Critical Care Posters

PRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PM

PURPOSE: To compare outcome of patients suffered from AKI due to septic and non-septic etiology.

METHODS: Patients admitted to our ICU between march 2010 to march 2012 ,screened for AKI using RIFLE criteria , grade I (RISK), II (INJURY) , III (FAILURE) and divided into two groups as septic and non-septic etiologies. Two groups were compared using -mean age, icu stay , need of hemodialysis / RRT ,refractory pulmonary edema , metabolic acidosis ,uremic encephalopathy , hyperkalemia , (MODS) multiorgan dysfunction and mortality. Statistical analysis done using SPSS version 16 with mean ,standard deviation , z score ,chi-square test and multivariate analysis.

RESULTS: patients in the septic group had statistically significant increased icu stay , need of RRT, incidence of refractory acidosis , hyperkalemia ,uremic encephalopathy and mortality .

CONCLUSIONS: Even though the criteria to diagnose AKI is equally sensitive for both sepsis and non-sepsis etiology , patients in the sepsis group deteriorated more rapidly ,had higher incidence of life threatening complications and mortality.They had higher average icu stay and increased cost of treatment.

CLINICAL IMPLICATIONS: Tight screening for sepsis related AKI and more aggressive management is required .Early hemodialysis / RRT should be initiated rather than awaiting for complications to occur. This will definitely reduce the burden of sepsis related in hospital mortality and expenses.

DISCLOSURE: The following authors have nothing to disclose: Prakash Gore, Sanjay Srivastava

No Product/Research Disclosure Information

Tata Motors Hospital., Jamshedpur, India




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