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Chest Infections |

Concordance of the Interferon-γ Release Assay (IGRA) and the Tuberculin Skin Test (TST) for the Screening of Tuberculosis Infection in the Inflammatory Rheumatic Disease (IRD) Population

Mediha Ortaköylü*, MD; Ayse Bahadir, MD; Derya Soy, MD; Emel Caglar, MD; Nurdan Paker, MD; Figen Alkan, MD; Kaya Koksalan, MD; Ekrem Seyhan, MD
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Yedikule Chest Diseases and Chest Surgery, Training and Research Hospital, Istanbul, Turkey


Chest. 2012;142(4_MeetingAbstracts):211A. doi:10.1378/chest.1389092
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Abstract

SESSION TYPE: Respiratory Infections Posters I

PRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PM

PURPOSE: Screening for active tuberculosis (TB) and latent TB infection (LTBI) is mandatory prior to the initiation of tumour necrosis factor-α inhibitor therapy. However, no agreement exists on the best strategy for detecting LTBI in this population. We tested the diagnostic performance of tuberculin skin tes (TST) interferon-gamma (IFN-γ) inducible protein 10 (IP-10) and IFN-γ for detecting LTBI in rheumatic diseases patients.

METHODS: 76 rheumatic diseases patients (26 rheumatoid arthritis,50 ankilosing spondilytis)were included.IP-10 levels were determined by enzyme-linked immunosorbent assay . TST was performed using the Mantoux method and was scored as positive if induration diameter was equal or > 5 mm . QFT-G was performed by measuring IFN-γ levels in whole blood treated with TB-specific antigens.

RESULTS: 59.8 % TST-positive patients were defined as having LTBI. Agreement between TST, QFT and IP-10 results were assesmented.Agreement between QFT and TST was poor (k= 0,21), it was poor between IP-10 and TST( k=0,17),it was good between QFT and IP-10 (k= 0,64 )

CONCLUSIONS: we concluded that IGRA tests were more useful diagnostic methods than TST for detecting LTBI in inflammatory rheumatic patients

CLINICAL IMPLICATIONS: further studies with more sensitive tests than TST for LTBI diagnosis in specialy disease groups as IRD patients are needed.

DISCLOSURE: The following authors have nothing to disclose: Mediha Ortaköylü, Ayse Bahadir, Derya Soy, Emel Caglar, Nurdan Paker, Figen Alkan, Kaya Koksalan, Ekrem Seyhan

No Product/Research Disclosure Information

Yedikule Chest Diseases and Chest Surgery, Training and Research Hospital, Istanbul, Turkey

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