Obstructive Lung Diseases |

Physiological Changes Using Dyspnea Recovery From Moderate Exacerbations of COPD FREE TO VIEW

Xubin Huang*, MD; Canmao Xie, MD; Yingshuo Yan, MD; Jianqiang Huang, MD; Xinyan Huang, MD
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The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

Chest. 2012;142(4_MeetingAbstracts):660A. doi:10.1378/chest.1389090
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PRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PM

PURPOSE: To determine the potential practical utility of using simple inspiratory capacity (IC) measurements to evaluate the severity and recovery of AECOPD, the reliability of this measurement to track changes in EELV was assessed.

METHODS: A prospective, observational study was conducted where patients diagnosed as having an AECOPD, who did not require mechanical ventilation, were referred for detailed physiological testing and symptom assessment and, thereafter, followed at pre-determined intervals over a 42-day period. Spirometry, lung volume, lung mechanics and dyspnea measurements were assessed at the visit of AECOPD, Day 14 and Day 42.

RESULTS: Significant improvements were seen in IC (p<0.001), maximal inspiratory pressure (MIP) (p=0.012), vital capacity(VC) (p<0.001), forced expiratory volume (FVC) (p=0.003), EELV(p<0.001) and residual volume (RV) (p<0.001) during dyspnea recovery of AECOPD, with a small increase in FEV1(p<0.01), and constant total lung capacity (TLC) (p=0.315) and specific airway resistance (sRaw) (p=0.091).

CONCLUSIONS: AECOPD, not associated with respiratory failure, is characterized by worsening lung hyperinflation. Improvement of dyspnoea following AECOPD is associated with reduction in lung hyperinflation (increase in VC and IC) and consequent increase in expiratory flow rates. Change in IC reliably reflects change in EELV, as TLC remained unaltered during recovery from AECOPD.

CLINICAL IMPLICATIONS: Monitoring the change of IC, a simple and easy method, could be used to evaluate the severity and recovery of AECOPD.

DISCLOSURE: The following authors have nothing to disclose: Xubin Huang, Canmao Xie, Yingshuo Yan, Jianqiang Huang, Xinyan Huang

No Product/Research Disclosure Information

The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China




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