SESSION TYPE: Lung Cancer I
PRESENTED ON: Sunday, October 21, 2012 at 10:30 AM - 11:45 AM
PURPOSE: The dichotomous limited and extensive disease classification has been widely employed for small cell lung cancer (SCLC). However, the IASLC proposed that UICC-7 TNM classification should be incorporated into clinical practice. The purpose of this study is to evaluate the applicability of UICC-7 TNM classification to SCLC.
METHODS: Between March 2005 and January 2010, consecutive patients who were confirmed as histology proven SCLC were included in this retrospective study. All study patients underwent routine clinical staging evaluations including positron emission tomography / computed tomography scan. Patients with concurrent other malignancy were excluded from the study. We compared the overall survival (OS) of the study patients in relation to T descriptors, N descriptors, M descriptors, and TNM stage grouping.
RESULTS: A total of 254 SCLC patients were included in the study. Median age was 64 years and male were 89.0%. Median OS was 14.1 months. There were no significant differences of OS according to T descriptors (P=0.872). However, there were significant differences of OS according to N descriptors (P=0.001) and M descriptors (P<0.001). Moreover, there were significant differences of OS in relation to TNM stage grouping (P<0.001). The hazard ratios for OS, adjusted for prognostic factors (age, ECOG, LDH, and albumin level) were significantly different according to N descriptors, M descriptors, and TNM stage grouping, however, there were no differences according to T descriptors.
CONCLUSIONS: UICC-7 TNM staging system can contribute to more precise prediction of prognosis of patients with SCLC patients. Further prospective validation studies are required for the evaluation of applicability of UICC-7 TNM classification to SCLC in clinical trials.
CLINICAL IMPLICATIONS: UICC-7 TNM staging system can contribute to more precise prediction of prognosis of patients with SCLC patients.
DISCLOSURE: The following authors have nothing to disclose: Byung Woo Jhun, Kyung Jong Lee, Kyeong Man Jeon, Won-Jung Koh, Gee Young Suh, Man Pyo Chung, Ho Joong Kim, Sang-Won Um
No Product/Research Disclosure InformationSamsung Medical Center, Seoul, Republic of Korea