0
Pulmonary Vascular Disease |

Role of Collagen Metabolism in Idiopathic, Anorexigen, and Hereditary Pulmonary Arterial Hypertension

Zeenat Safdar*, MD
Author and Funding Information

Baylor College of Medicine, Houston, TX


Chest. 2012;142(4_MeetingAbstracts):811A. doi:10.1378/chest.1388582
Text Size: A A A
Published online

Abstract

SESSION TYPE: Pulmonary Hypertension II

PRESENTED ON: Monday, October 22, 2012 at 04:00 PM - 05:30 PM

PURPOSE: Pulmonary Arterial Hypertension (PAH) has a high mortality and is characterized by pulmonary vascular remodeling. Collagen metabolism is regulated by matrix metalloproteinases (MMPs) that influence vascular remodeling, and activity of MMPs is tightly regulated by tissue inhibitor of MMPs (TIMPs). Aim of this study was to determine circulating levels of MMP and TIMP in a cohort of PAH patients.

METHODS: After obtaining informed consent, 59 idiopathic, anorexigen and hereditary PAH subjects were prospectively enrolled from the Baylor Pulmonary Hypertension Center and 28 age- and gender-matched healthy controls were enrolled from Baylor Medicine Clinic. Serum was separated from peripheral venous blood samples, and stored at -80 degree C before undergoing simultaneous analysis. Serum MMP-9 and TIMP-1 were measured by 2-site sandwich ELISAs (R&D systems).

RESULTS: Age of the control subjects was 47.5±14 years (mean± SD) whereas age of the PAH subjects was 45±14 years (p=0.34). BSA was similar between the two groups (p=0.36). Six-minute walk distance (6MWD) was lower in the PAH group (403±102 meters vs 467±71 meters, p=0.005) whereas BNP levels were higher in the PAH group (121±182 pg/ml vs. 16.3±7 pg/ml, p=0.009). MMP-9 levels were elevated in the PAH group (p=0.001) and TIMP-1 levels were lower in the control group (p<0.001). There was no correlation between MMP-9 and TIMP-1 levels, and 6MWD, Borg Dyspnea Score and BNP levels; however there was a weak negative correlation between MMP-9 and TIMP-1 levels and cardiac index (-0.2; p=0.06).

CONCLUSIONS: In PAH patients, MMP-9 and TIMP-1 levels are elevated and may indicate worse disease.

CLINICAL IMPLICATIONS: Circulating collagen biomarkers may be helpful in supporting new diagnostic and therapeutic strategies in PAH.

DISCLOSURE: Zeenat Safdar: Consultant fee, speaker bureau, advisory committee, etc.: Actelion, Gilead Sciences, United Therapeutics

will discuss the role of circulating markers of collagen metabolism (MMP and TIMPs) in this presentation

Baylor College of Medicine, Houston, TX

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543