Obstructive Lung Diseases |

Asthma Can Present With Nonobstructive Pattern in Spirometry FREE TO VIEW

Tarig Merghani*, PhD; Mohammed Alameen, RCP
Author and Funding Information

University of Khartoum, Khartoum, Sudan

Chest. 2012;142(4_MeetingAbstracts):706A. doi:10.1378/chest.1388359
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SESSION TYPE: Asthma Posters

PRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PM

PURPOSE: Asthmatic patients typically show obstructive patterns on spirometry; with positive responses to bronchodilators. In some patients, the only evidence of obstruction might be low values of forced expiratory flow (FEF), indicating inflammation within middle and small airways of the lung. However, the normal range of this parameter is very wide and it is not as reproducible as the forced expiratory volume in the first second (FEV1). On the other hand, the common practice is to exclude asthma in a symptomatic patient showing non-obstructive pattern of spirometry. This study aims to determine patterns of spirometry among patients presenting with symptoms and signs of mild to moderate asthma.

METHODS: A sample of 177 known asthmatic patients (96 females and 81 males) was selected from those attending respiratory clinic of Yastabshiron Hospital in Khartoum for follow up. A portable spirometer (All flow, Clement Clarke International, UK) was used for measurement of FEV1, FVC, FEV1/FVC ratio and PEF for each patient. Measurements were carried out, according to American Thoracic Society guidelines, on presentation and then 15 minutes following inhalation of 0.5 mg salbutamol using a spacer.

RESULTS: Typical obstructive pattern was found in only 26.6% of patients, normal pattern in 19.8%, restrictive in 33.3% and combined pattern in 20.3%. Significant proportions of all patterns showed positive reversibility tests (P<0.05). No correlation was found between body mass index (BMI) and patterns of spirometry.

CONCLUSIONS: It is concluded that patients with mild to moderate asthma may show non-obstructive patterns in spirometry with positive response to bronchodilators.

CLINICAL IMPLICATIONS: Reversibility tests should be performed for all symptomatic patients suspected of asthma, irrespective of their spirometric pattern.

DISCLOSURE: The following authors have nothing to disclose: Tarig Merghani, Mohammed Alameen

We have conducted spirometry with standard technique

University of Khartoum, Khartoum, Sudan




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