SESSION TYPE: New Insights into Idiopathic Pulmonary Fibrosis
PRESENTED ON: Sunday, October 21, 2012 at 01:15 PM - 02:45 PM
PURPOSE: There is a controversy that the older patients with IPF have worse prognosis. We evaluated whether age can affect survival and there are differences of parameters affecting prognosis between each age group in patients with IPF.
METHODS: This retrospective observational study consisted of 1,685 patients with IPF by clinical(1,027 patients) or surgical(658 patients) diagnosis defined by the 2000 ATS/ERS consensus statement. Patients were enrolled from 54 hospitals in Korea from January 1, 2003 to December 31, 2007. There were 465 women and 1,220 men, with a mean age of 67.9(range, 30 to 94) years. They were stratified by four age groups(younger than 50 years, n=65; 50-60 years, n=252; 60-70 years, n=623; older than 70 years, n=748). We used life-table method to estimate the overall survival time. We analyzed whether there were baseline clinical characteristic differences between groups: on presence of exertional dyspnea and on presence of honeycombing by Pearson chi-square test; on diffusion capacity for carbon monoxide(DLCO,%) by ANOVA test.
RESULTS: The median survival time from the time of the diagnosis was 57.3 months in 1,685 patients. The median survival time of the group of older than 70 years was significantly shorter than those of others:[< 50 years, 63.0 months; 50-60 years, 63.0 months; 60-70 years, 65.0 months; >70 years, 38.8 months (p=0.001)]. There was a significant difference in the presence of exertional dyspnea between each groups (p=0.018) but no difference between groups under 70 years old. There was no difference on the presence of honeycomb between each groups (p=0.279). There was a significant difference in DLCO between groups (p=0.048) but no difference between each group in post hoc tests.
CONCLUSIONS: The overall survival time of the group of older than 70 years was significantly shorter than those of others and exertional dyspnea can predict poor prognosis in patients with IPF in Korean population.
CLINICAL IMPLICATIONS: Patients more than 70 years old with IPF have a poor prognosis. The baseline clinical characteristic differences between groups might influence the survival time.
DISCLOSURE: The following authors have nothing to disclose: So-My Koo, Soo-Taek Uh, Dong Soon Kim, Choon Sik Park
No Product/Research Disclosure InformationDivision of Allergy and Respiratory Medicine, Department of Internal Medicine, Soon Chun Hyang University Seoul Hospital, Seoul, Republic of Korea